Basic information
- Phenotype
- PROGENy: Estrogen
- Description
- Score representing the activity of the estrogen-activated pathway. It was calculated using the PROGENy tool on the RNA data (genes with mean FPKM expression >0).
- Source
- https://www.nature.com/articles/s41467-017-02391-6; https://www.sciencedirect.com/science/article/abs/pii/S1874939919302287?via%3Dihub
- Method
- The PROGENy scores were inferred using the R package progeny (V1.10.0) (PMID: 29295995) with default parameters using the RNA expression data (FPKM). Genes with mean expression = 0 in a cohort were removed from the analysis.
- Genes
-
- ADCY9
- ADORA1
- ARL3
- ARMCX6
- ASB13
- ATP2A3
- C5AR2
- CA12
- CAB39L
- CALCR
- CAP2
- CASP9
- CELSR2
- CLDN4
- CLDN9
- COMT
- CTNND2
- CTR9
- CXCL12
- DDX10
- DEPTOR
- DSCAM
- EGR3
- ELF5
- ELOVL2
- EPB41L5
- EPS15L1
- ERBB3
- ESR1
- FAM102A
- FGFR1OP
- FKBP4
- FRK
- GATA3
- GLA
- GREB1
- HDAC7
- HEY2
- IGFBP4
- IL17RB
- IL1R1
- KCNJ3
- KCNK5
- KIAA0513
- MED13L
- MISP
- MPPED2
- MSMB
- MYB
- MYH14
- MYO1B
- NKAIN1
- NPY1R
- NR5A2
- NRIP1
- OLFM1
- PCP4
- PGR
- PIK3R3
- PLAC1
- PLPP2
- PPIF
- PRSS23
- RAB27B
- RAB9A
- RAPGEFL1
- RARA
- RBBP8
- RCL1
- RET
- RHBDF1
- RLN2
- RNF43
- SDK2
- SEC14L2
- SGCG
- SH3BP4
- SIAH2
- SIDT1
- SLC22A5
- SLC25A24
- SLC7A5
- SLC9A1
- SNX24
- STC2
- TACC1
- TFF1
- TGFB3
- TIAM1
- TLE1
- TMEM135
- TPD52L1
- UPK2
- WFS1
- WWC1
- XBP1
- ZDHHC7
- ZNF552
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
| Signed p-values | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with PROGENy: Estrogen to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
| Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with PROGENy: Estrogen to WebGestalt.