Basic information
- Phenotype
- HALLMARK_FATTY_ACID_METABOLISM
- Description
- Enrichment score representing genes involved in fatty acid metabolism. The score was calculated using ssGSEA on the RNA data (Z-score transformed coding genes with expression in at least 50% of the samples in a cohort).
- Source
- http://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM.html
- Method
- Single sample gene set enrichment analysis (ssGSEA) was performed for each cancer type using gene-wise Z-scores of the RNA expression data (RSEM) for the MSigDB Hallmark gene sets v7.0 (PMID: 26771021) via the ssGSEA2.0 R package (PMID: 30563849). RNA data were filtered to coding genes with < 50% 0 expression. (Parameters: sample.norm.type="rank", weight=0.75, statistic="area.under.RES", nperm=1000, min.overlap=10). Pathway activity scores are normalized enrichment scores from ssGSEA.
- Genes
-
- ACAA1
- ACAA2
- ACADL
- ACADM
- ACADS
- ACADVL
- ACAT2
- ACO2
- ACOT2
- ACOT8
- ACOX1
- ACSL1
- ACSL4
- ACSL5
- ACSM3
- Array
- ACSS1
- ADH1C
- ADH7
- ADIPOR2
- ADSL
- ALAD
- ALDH1A1
- ALDH3A1
- ALDH3A2
- ALDH9A1
- ALDOA
- AOC3
- APEX1
- AQP7
- AUH
- BCKDHB
- BLVRA
- BMPR1B
- BPHL
- CA2
- CA4
- CA6
- CBR1
- CBR3
- CCDC58
- CD1D
- CD36
- CEL
- CIDEA
- CPOX
- CPT1A
- CPT2
- CRAT
- CRYZ
- CYP1A1
- CYP4A11
- CYP4A22
- D2HGDH
- DECR1
- DHCR24
- DLD
- DLST
- ECH1
- ECHS1
- ECI1
- ECI2
- EHHADH
- ELOVL5
- ENO2
- ENO3
- EPHX1
- ERP29
- ETFDH
- FABP1
- FABP2
- FASN
- FH
- FMO1
- G0S2
- GABARAPL1
- GAD2
- GAPDHS
- GCDH
- GLUL
- GPD1
- GPD2
- GRHPR
- GSTZ1
- H2AZ1
- HADH
- HADHB
- HAO2
- HCCS
- HIBCH
- HMGCL
- HMGCS1
- HMGCS2
- HPGD
- HSD17B10
- HSD17B11
- HSD17B4
- HSD17B7
- HSDL2
- HSP90AA1
- HSPH1
- IDH1
- IDH3B
- IDH3G
- IDI1
- IL4I1
- INMT
- KMT5A
- LDHA
- LGALS1
- LTC4S
- MAOA
- MCEE
- MDH1
- MDH2
- ME1
- METAP1
- MGLL
- MIF
- MLYCD
- NBN
- NCAPH2
- NSDHL
- NTHL1
- ODC1
- OSTC
- PCBD1
- PDHA1
- PDHB
- PPARA
- PRDX6
- PSME1
- PTPRG
- PTS
- RAP1GDS1
- RDH11
- RDH16
- REEP6
- RETSAT
- S100A10
- SDHA
- SDHC
- SDHD
- SERINC1
- SLC22A5
- SMS
- SUCLA2
- SUCLG1
- SUCLG2
- TDO2
- TP53INP2
- UBE2L6
- UGDH
- UROD
- UROS
- VNN1
- YWHAH
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
| Signed p-values | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with HALLMARK_FATTY_ACID_METABOLISM to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
| Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with HALLMARK_FATTY_ACID_METABOLISM to WebGestalt.