Gene: PPARA

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
peroxisome proliferator activated receptor alpha
Ensembl
ENSG00000186951.16
Summary
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
Annotation
Transcription factor Druggable target (Tier T4)

Protein product

  • ENST00000407236.5 Primary ENSP00000385523.1 (0 phosphosite)
  • ENST00000262735.9
  • ENST00000402126.1
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-7.5e-5--6.9e-27---2.9e-93.6e-140.023--0.043-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC67891011121314log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910110-1-2-3-4-5-6-7-8-9-10-11Pan-cancer02468101214160-2-4-6-8-10-12-14-16proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PPARA with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: Myeloid dendritic cell activated-----------
PROGENy: Estrogen-----------
PROGENy: JAK-STAT-----------
PROGENy: NFkB-----------
PROGENy: TGFb-----------
PROGENy: WNT-----------
PERT-PSP_NOCODAZOLE-----------
PERT-PSP_EGF-----------
PERT-P100-DIA_STAUROSPORINE-----------
PATH-NP_TSLP_PATHWAY-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PPARA

BRCA0.42proteinmRNASCNVmethylationCCRCC-0.140.10-0.13proteinmRNASCNVmethylationCOAD0.27proteinmRNASCNVmethylationGBM-0.040.460.07proteinmRNASCNVmethylationHNSCC-0.090.290.06proteinmRNASCNVmethylationLSCC0.140.570.21proteinmRNASCNVmethylationLUAD-0.130.44-0.04proteinmRNASCNVmethylationOV0.59proteinmRNASCNVmethylationPDAC-0.010.280.03proteinmRNASCNVmethylationUCEC-0.010.12-0.02proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PPARA and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.