Basic information
- Phenotype
- cibersort: Macrophage M1
- Description
- Estimated fraction of M1 macrophages in the tumor compared to 21 other immune cells defined by CIBERSORT based on RNA expression data.
- Source
- https://www.nature.com/articles/nmeth.3337
- Method
- The R package immunedeconv (V2.0.4) (PMID: 31510660) was used to perform immune cell deconvolution using RNA expression data (TPM). CIBERSORT (PMID: 25822800) was performed in the ‘abs’ mode.
- Genes
-
- ACP5
- ADAMDEC1
- ADRB2
- AIF1
- AIM2
- APOBEC3A
- APOBEC3G
- APOL3
- APOL6
- AQP9
- ARRB1
- BCL2A1
- BIRC3
- BMP2K
- C1orf54
- C3AR1
- CASP5
- CCL14
- CCL18
- CCL19
- CCL20
- CCL23
- CCL4
- CCL5
- CCL8
- CCR5
- CCR7
- CD38
- CD4
- CD40
- CD68
- CD80
- CD86
- CHI3L1
- CHI3L2
- CLEC2D
- CLIC2
- CSF3R
- CXCL10
- CXCL11
- CXCL13
- CXCL9
- CYP27B1
- DHX58
- DUSP2
- EBI3
- FLVCR2
- FPR1
- FPR3
- GPR183
- HCK
- HESX1
- HLA-DOB
- HLA-DQA1
- HPSE
- IDO1
- IFI44L
- IL12B
- IL1B
- IL2RA
- IL4R
- IL7R
- IRF8
- KYNU
- LAG3
- LAMP3
- LILRB2
- LST1
- LY86
- MMP25
- MMP9
- MNDA
- MSC
- NCF2
- NOD2
- PLA1A
- PLA2G7
- PLEKHG3
- PTGIR
- RASGRP3
- RASSF4
- RENBP
- RSAD2
- SAMSN1
- SIGLEC1
- SLAMF1
- SLAMF8
- SLC15A3
- SLC2A6
- SLCO5A1
- SOCS1
- SPIB
- TBX21
- TLR2
- TLR7
- TLR8
- TNFAIP6
- TNFRSF4
- TNIP3
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
| Signed p-values | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with cibersort: Macrophage M1 to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
| Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with cibersort: Macrophage M1 to WebGestalt.