Basic information
- Full name
- KRAS proto-oncogene, GTPase
- Ensembl
- ENSG00000133703.13
- Summary
- This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
- Annotation
- Cancer driver (Oncogene) Essential genes Druggable target (Tier T1)
Protein product
- ENST00000256078.10 Primary ENSP00000256078.5 (1 phosphosite)
- ENST00000311936.8
- ENST00000557334.5
- ENST00000556131.1
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 6e-22 | - | -0.68 | - | - | 0.19 | 6e-18 | 2.8e-11 | - | 9.5e-8 | - |
protein | -1.8e-20 | - | -5.9e-14 | -6.1e-13 | - | -0.005 | -4.3e-10 | -8.1e-18 | 0.006 | 3.1e-7 | -0.081 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of KRAS with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
KRAS mutation | 1.3e-5 | - | - | 0.034 | - | - | - | 1.7e-3 | - | - | 0.022 | |
Tumor Purity (WGS) | 3.2e-5 | - | -0.031 | - | 0.47 | 3.7e-3 | 0.008 | 0.11 | - | 0.042 | 1.1e-3 | |
KINASE-PSP_ERK2/MAPK1 | 6.3e-5 | 0.98 | 0.51 | 0.5 | 0.82 | 4.5e-3 | 7.7e-3 | 0.77 | 0.25 | 7.4e-3 | 0.15 | |
Tumor Purity (ABSOLUTE) | 5.7e-4 | 0.85 | -0.033 | 0.14 | 0.67 | 6.1e-4 | 0.03 | 0.94 | 0.11 | 0.27 | 9.8e-3 | |
chromosomal instability | 2.4e-3 | -0.66 | -0.21 | 0.076 | 0.57 | 3.5e-3 | 0.041 | 0.65 | 0.092 | 0.62 | 0.17 | |
DISEASE-PSP_Alzheimer's_disease | 2.7e-3 | - | - | - | 2.8e-5 | - | - | - | - | - | 0.97 | |
cibersort: T cell CD4+ naive | 0.011 | - | - | - | 0.27 | 0.19 | 0.22 | 0.74 | -0.92 | 0.032 | 0.48 | |
KINASE-PSP_CDK5 | 0.013 | - | - | - | 0.017 | -0.67 | 0.75 | - | - | 0.26 | 0.029 | |
KINASE-PSP_ERK1/MAPK3 | 0.021 | -0.047 | 0.17 | 0.11 | -0.82 | 0.51 | 0.4 | 0.3 | 0.85 | 0.031 | 0.092 | |
xcell: Eosinophil | 0.03 | 0.6 | 0.026 | 0.12 | 0.35 | 0.75 | -0.14 | 0.38 | 0.36 | 0.6 | 0.66 |
Cis-association
Associations between omics data of KRAS
Trans-association
Associations of the protein abundance of KRAS and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.