Basic information

Full name
KRAS proto-oncogene, GTPase
Ensembl
ENSG00000133703.13
Summary
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
Annotation
Cancer driver (Oncogene) Essential genes Druggable target (Tier T1)

Protein product

Phosphosites on the primary protein product
Loading...

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA6e-22--0.68--0.196e-182.8e-11-9.5e-8-
protein-1.8e-20--5.9e-14-6.1e-13--0.005-4.3e-10-8.1e-180.0063.1e-7-0.081

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC891011121314151617log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC20212223242526272829log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567890-1-2-3-4-5-6-7-8-9Pan-cancer02468101214160-2-4-6-8-10-12-14-16proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of KRAS with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KRAS mutation1.3e-5--0.034---1.7e-3--0.022
Tumor Purity (WGS)3.2e-5--0.031-0.473.7e-30.0080.11-0.0421.1e-3
KINASE-PSP_ERK2/MAPK16.3e-50.980.510.50.824.5e-37.7e-30.770.257.4e-30.15
Tumor Purity (ABSOLUTE)5.7e-40.85-0.0330.140.676.1e-40.030.940.110.279.8e-3
chromosomal instability2.4e-3-0.66-0.210.0760.573.5e-30.0410.650.0920.620.17
DISEASE-PSP_Alzheimer's_disease2.7e-3---2.8e-5-----0.97
cibersort: T cell CD4+ naive0.011---0.270.190.220.74-0.920.0320.48
KINASE-PSP_CDK50.013---0.017-0.670.75--0.260.029
KINASE-PSP_ERK1/MAPK30.021-0.0470.170.11-0.820.510.40.30.850.0310.092
xcell: Eosinophil0.030.60.0260.120.350.75-0.140.380.360.60.66
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of KRAS

BRCA0.16-0.050.32proteinmRNASCNVmethylationCCRCC0.180.010.03-0.090.16-0.19proteinmRNASCNVmethylationCOAD0.110.220.55proteinmRNASCNVmethylationGBM0.09-0.130.010.040.23-0.04proteinmRNASCNVmethylationHNSCC0.36-0.370.33-0.260.66-0.26proteinmRNASCNVmethylationLSCC0.46-0.260.53-0.260.68-0.24proteinmRNASCNVmethylationLUAD0.41-0.110.22-0.200.59-0.24proteinmRNASCNVmethylationOV0.210.280.75proteinmRNASCNVmethylationPDAC0.27-0.200.17-0.010.41-0.21proteinmRNASCNVmethylationUCEC0.250.130.260.180.27-0.23proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of KRAS and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.