Basic information
- Phenotype
- cibersort: T cell CD4+ memory activated
- Description
- Estimated fraction of activated memory CD4+ T cells in the tumor compared to 21 other immune cells defined by CIBERSORT based on RNA expression data.
- Source
- https://www.nature.com/articles/nmeth.3337
- Method
- The R package immunedeconv (V2.0.4) (PMID: 31510660) was used to perform immune cell deconvolution using RNA expression data (TPM). CIBERSORT (PMID: 25822800) was performed in the ‘abs’ mode.
- Genes
-
- APOBEC3G
- Array
- APOL3
- BACH2
- BCL11B
- Array
- Array
- Array
- BCL2A1
- Array
- BIRC3
- CCL20
- CCL4
- CCL5
- CCND2
- CCR7
- CD2
- CD247
- CD27
- CD28
- CD37
- CD38
- CD3D
- CD3E
- CD3G
- CD4
- CD40LG
- CD5
- CD6
- CD69
- CD7
- CLEC2D
- CRTAM
- CSF2
- CST7
- CTLA4
- CXCL10
- CXCR6
- DGKA
- DPP4
- DUSP2
- EGR2
- ETS1
- FASLG
- FOXP3
- GFI1
- GPR171
- GPR18
- GPR183
- GPR65
- GZMA
- GZMB
- GZMH
- GZMM
- HPSE
- ICOS
- IFNG
- IL12RB2
- IL2RA
- IL2RB
- IL3
- IL4R
- IL7R
- IL9
- IRF8
- ITK
- KLRB1
- LAG3
- LAT
- LCK
- LTA
- LTB
- MAP4K1
- MYB
- NKG7
- ORC1
- P2RX5
- PASK
- PIK3IP1
- PLEKHF1
- PRF1
- PTGER2
- PTPRCAP
- PVRIG
- RGS1
- RRP9
- SAMSN1
- SELL
- SH2D1A
- SIT1
- SKAP1
- SLAMF1
- SOCS1
- SPOCK2
- TBX21
- TNFRSF4
- TNIP3
- TRAT1
- ZAP70
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
Signed p-values | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
| No matching records found | ||||||||||||
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with cibersort: T cell CD4+ memory activated to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
| No matching records found | |||||||||||||
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with cibersort: T cell CD4+ memory activated to WebGestalt.