Gene: CCND2

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
cyclin D2
Ensembl
ENSG00000118971.8
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
Annotation
Cancer driver (Oncogene)

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-6.3e-5-5.9e-18--0.28-3.3e-4-6.4e-22--4.9e-7-
protein-6.1e-3-----6.1e-3-----

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC67891011121314151617log2(RSEM+1)tumornormal
Protein expression
BRCAHNSCCLSCCLUADOVPDAC121314151617181920log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820220-2-4-6-8-10-12-14-16-18-20-22Pan-cancer024681012141618202224260-2-4-6-8-10-12-14-16-18-20-22-24-26proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CCND2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Macrophage4.4e-4----0.032-4.8e-3---
xcell: Macrophage M11.5e-3----0.069-7.5e-3---
xcell: Macrophage M20.002----0.022-0.038---
HALLMARK_KRAS_SIGNALING_UP2.7e-3----0.16-4.8e-3---
HALLMARK_COAGULATION3.5e-3----0.078-0.018---
HALLMARK_COMPLEMENT5.2e-3----0.18-8.8e-3---
HALLMARK_UV_RESPONSE_DN6.5e-3----0.093-0.03---
HALLMARK_NOTCH_SIGNALING0.01----0.2-0.02---
ESTIMATE: ImmuneScore0.014----0.2-0.029---
ESTIMATE: ESTIMATEScore0.015----0.055-0.13---
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CCND2

BRCA0.08proteinmRNASCNVmethylationCCRCC-0.320.110.05proteinmRNASCNVmethylationCOAD0.18proteinmRNASCNVmethylationGBM0.350.010.01proteinmRNASCNVmethylationHNSCC-0.07-0.24-0.08-0.360.15-0.14proteinmRNASCNVmethylationLSCC-0.150.23-0.11proteinmRNASCNVmethylationLUAD0.56-0.19-0.22-0.220.10-0.07proteinmRNASCNVmethylationOV0.26proteinmRNASCNVmethylationPDAC-0.120.07-0.17proteinmRNASCNVmethylationUCEC-0.300.04-0.08proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CCND2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.