Basic information
- Phenotype
- cibersort: T cell regulatory (Tregs)
- Description
- Estimated fraction of regulatory T cells (Tregs) in the tumor compared to 21 other immune cells defined by CIBERSORT based on RNA expression data.
- Source
- https://www.nature.com/articles/nmeth.3337
- Method
- The R package immunedeconv (V2.0.4) (PMID: 31510660) was used to perform immune cell deconvolution using RNA expression data (TPM). CIBERSORT (PMID: 25822800) was performed in the ‘abs’ mode.
- Genes
-
- APOBEC3G
- APOL3
- CCND2
- CD28
- CD38
- CD3G
- Array
- CD79B
- CRISP3
- CST7
- CXCR6
- DPP4
- ETS1
- FLT3LG
- FRMD8
- GPR65
- GZMM
- HLA-DQA1
- ICOS
- KLRB1
- LAG3
- MYB
- NCR3
- NPIPB15
- P2RX5
- P2RY10
- PASK
- PLCH2
- PRF1
- PTGIR
- RASGRP2
- RGS1
- RSAD2
- RYR1
- SEC31B
- SIK1
- SLAMF1
- SOCS1
- SP140
- ST6GALNAC4
- STAP1
- TCF7
- TNFRSF11A
- Array
- Array
- TRIB2
- TYR
- UBASH3A
- ZAP70
- Array
- ACAP1
- BCL11B
- BIRC3
- CCR7
- CD2
- CD247
- CD27
- CD37
- CD3D
- CD3E
- CD4
- CD5
- CD6
- CD7
- CD70
- CD96
- CLEC2D
- CTLA4
- DGKA
- FOXP3
- GPR171
- IFI44L
- IL2RA
- IL2RB
- IL4R
- ITK
- LAIR2
- LAT
- LCK
- LTB
- MAP4K1
- PBXIP1
- PIK3IP1
- PMCH
- Array
- PTGER2
- PTPRCAP
- PVRIG
- SAMSN1
- SELL
- SH2D1A
- SIRPG
- SIT1
- SKAP1
- SPOCK2
- TNFRSF4
- ZFP36L2
- Array
- Array
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
.png)
Association of protein abundance of genes
Signed p-values | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
| No matching records found | ||||||||||||
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with cibersort: T cell regulatory (Tregs) to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
.png)
Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
| No matching records found | |||||||||||||
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with cibersort: T cell regulatory (Tregs) to WebGestalt.