Basic information
- Phenotype
- xcell: NK cell
- Description
- Enrichment score inferring the proportion of NK cells in the tumor derived from RNA data using the xCell tool.
- Source
- https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1349-1
- Method
- The R package immunedeconv (V2.0.4) (PMID: 31510660) was used to perform immune cell deconvolution using RNA expression data (TPM).
- Genes
-
- ALG13
- AMZ2
- ANKRD11
- ARPC5L
- ASTE1
- BAD
- BRD2
- C1orf174
- CCL4
- CD160
- CD244
- CD247
- CDKN2AIP
- CHRNE
- COQ10B
- CTSW
- CX3CR1
- DNAJB14
- DNAJC2
- DR1
- FASLG
- FBXW4
- FIP1L1
- GGPS1
- GIPR
- GNA13
- GNLY
- GOLGA4
- GPATCH8
- GRIK4
- GTF3C1
- GZMB
- GZMH
- GZMM
- HELZ
- HIPK1
- HNRNPL
- IFNG
- IL18RAP
- IL21R
- IL2RB
- KLRD1
- KLRG1
- KPNB1
- LAG3
- LEMD3
- LIM2
- LTA
- MAP3K7
- MAPK1
- MED1
- MGAT2
- MLH1
- NCR1
- NCR3
- NEK1
- NFE2L2
- NKG7
- NMUR1
- OSBPL7
- PJA2
- PPP2CA
- PRDM2
- PRDX6
- PRF1
- PRKAG1
- PTGDR
- PTPN4
- RAB14
- RBM25
- RBM39
- RGS9
- RSRC2
- SACM1L
- SBF1
- SF3B4
- SON
- STAG2
- STX8
- SUPV3L1
- TBCC
- TBX21
- THAP1
- TKTL1
- TNFSF11
- TSPYL1
- TSTD2
- UBE2Q1
- WBP11
- WDR45
- XCL1
- YAF2
- ZBTB1
- ZBTB39
- ZMYND11
- ZNF264
- ZNF426
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
| Signed p-values | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with xcell: NK cell to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
| Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with xcell: NK cell to WebGestalt.