Basic information

Full name
actin related protein 1B
Ensembl
ENSG00000115073.8
Summary
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]

Protein product

  • ENST00000289228.7 Primary ENSP00000289228.5 (0 phosphosite)
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-4.1e-4-5.7e-6---2.2e-15-0.046-0.69--0.035-
protein-7.4e-46-9.7e-4-1.2e-16--3.7e-21-8.5e-29-1.6e-270.47-6.1e-4-0.29

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC8.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2323.52424.52525.52626.527log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer02468101214161820220-2-4-6-8-10-12-14-16-18-20-22proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ACTR1B with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_BILE_ACID_METABOLISM3e-130.0250.210.634.1e-30.118.3e-48.0e-41.1e-30.312.9e-4
xcell: Hematopoietic stem cell2e-105.1e-41.2e-3-0.910.199.1e-30.475.3e-6-0.240.021.6e-3
xcell: stroma score1.8e-96.9e-49.5e-3-0.88-0.630.0130.0191.5e-5-0.160.0174.4e-4
HALLMARK_HEDGEHOG_SIGNALING3.6e-80.270.0260.590.115.5e-30.241.8e-4-0.0431.2e-32.4e-3
PERT-P100-DIA_STAUROSPORINE1.1e-78.3e-3---0.820.730.0144.3e-6-2.9e-40.53
xcell: Cancer associated fibroblast1.2e-70.20.740.91-0.339.7e-32.5e-37.8e-6-0.448.4e-35.2e-5
HALLMARK_MYOGENESIS1.5e-70.0630.110.690.0134.1e-32.6e-33.4e-5-0.0150.390.071
KINASE-PSP_AMPKA1/PRKAA14.3e-7----0.89----2.2e-160.49
HALLMARK_UV_RESPONSE_DN5.8e-74.2e-4-0.810.240.624.9e-40.0526.0e-5-8.5e-30.0330.058
HALLMARK_HEME_METABOLISM1.7e-60.0240.120.793.6e-50.0432.4e-33.0e-40.96-0.37-0.37
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ACTR1B

BRCA0.470.280.41proteinmRNASCNVmethylationCCRCC0.55-0.060.13-0.040.24-0.21proteinmRNASCNVmethylationCOAD0.220.180.37proteinmRNASCNVmethylationGBM0.500.100.250.040.070.02proteinmRNASCNVmethylationHNSCC0.380.030.00-0.230.47-0.15proteinmRNASCNVmethylationLSCC0.57-0.090.26-0.080.30-0.13proteinmRNASCNVmethylationLUAD0.33-0.050.01-0.080.270.04proteinmRNASCNVmethylationOV0.610.160.34proteinmRNASCNVmethylationPDAC0.110.170.01-0.070.05-0.05proteinmRNASCNVmethylationUCEC0.27-0.02-0.04-0.010.210.01proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ACTR1B and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.