Basic information
- Full name
- actin related protein 1B
- Ensembl
- ENSG00000115073.8
- Summary
- This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]
Protein product
- ENST00000289228.7 Primary ENSP00000289228.5 (0 phosphosite)
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -4.1e-4 | - | 5.7e-6 | - | - | -2.2e-15 | -0.046 | -0.69 | - | -0.035 | - |
protein | -7.4e-46 | - | 9.7e-4 | -1.2e-16 | - | -3.7e-21 | -8.5e-29 | -1.6e-27 | 0.47 | -6.1e-4 | -0.29 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of ACTR1B with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_BILE_ACID_METABOLISM | 3e-13 | 0.025 | 0.21 | 0.63 | 4.1e-3 | 0.11 | 8.3e-4 | 8.0e-4 | 1.1e-3 | 0.31 | 2.9e-4 | |
xcell: Hematopoietic stem cell | 2e-10 | 5.1e-4 | 1.2e-3 | -0.91 | 0.19 | 9.1e-3 | 0.47 | 5.3e-6 | -0.24 | 0.02 | 1.6e-3 | |
xcell: stroma score | 1.8e-9 | 6.9e-4 | 9.5e-3 | -0.88 | -0.63 | 0.013 | 0.019 | 1.5e-5 | -0.16 | 0.017 | 4.4e-4 | |
HALLMARK_HEDGEHOG_SIGNALING | 3.6e-8 | 0.27 | 0.026 | 0.59 | 0.11 | 5.5e-3 | 0.24 | 1.8e-4 | -0.043 | 1.2e-3 | 2.4e-3 | |
PERT-P100-DIA_STAUROSPORINE | 1.1e-7 | 8.3e-3 | - | - | -0.82 | 0.73 | 0.014 | 4.3e-6 | - | 2.9e-4 | 0.53 | |
xcell: Cancer associated fibroblast | 1.2e-7 | 0.2 | 0.74 | 0.91 | -0.33 | 9.7e-3 | 2.5e-3 | 7.8e-6 | -0.44 | 8.4e-3 | 5.2e-5 | |
HALLMARK_MYOGENESIS | 1.5e-7 | 0.063 | 0.11 | 0.69 | 0.013 | 4.1e-3 | 2.6e-3 | 3.4e-5 | -0.015 | 0.39 | 0.071 | |
KINASE-PSP_AMPKA1/PRKAA1 | 4.3e-7 | - | - | - | -0.89 | - | - | - | - | 2.2e-16 | 0.49 | |
HALLMARK_UV_RESPONSE_DN | 5.8e-7 | 4.2e-4 | -0.81 | 0.24 | 0.62 | 4.9e-4 | 0.052 | 6.0e-5 | -8.5e-3 | 0.033 | 0.058 | |
HALLMARK_HEME_METABOLISM | 1.7e-6 | 0.024 | 0.12 | 0.79 | 3.6e-5 | 0.043 | 2.4e-3 | 3.0e-4 | 0.96 | -0.37 | -0.37 |
Cis-association
Associations between omics data of ACTR1B
Trans-association
Associations of the protein abundance of ACTR1B and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.