Basic information
- Full name
- cyclin and CBS domain divalent metal cation transport mediator 2
- Ensembl
- ENSG00000148842.18
- Summary
- This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
- Annotation
- Druggable target (Tier T5)
Protein product
- ENST00000369878.9 Primary ENSP00000358894.3 (7 phosphosites)
- ENST00000433628.2
- ENST00000369875.3
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -3.2e-82 | - | -1.3e-26 | - | - | -5.3e-17 | -3.6e-19 | -9.4e-28 | - | -5.6e-5 | - |
protein | -7.3e-4 | - | -2.6e-17 | - | - | 0.78 | 0.66 | 0.46 | - | - | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of CNNM2 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
DISEASE-PSP_Alzheimer's_disease | 1.4e-7 | - | - | - | 2.2e-16 | - | - | - | - | - | -0.45 | |
PROGENy: Estrogen | 5.6e-3 | 0.13 | 0.66 | 0.67 | -0.65 | -0.43 | 0.53 | 0.044 | - | 0.013 | 0.041 | |
xcell: Granulocyte-monocyte progenitor | 0.021 | -0.88 | 0.16 | 0.43 | -0.37 | 0.18 | 1.3e-3 | -0.96 | - | 0.62 | 0.45 | |
xcell: Neutrophil | 0.023 | -0.22 | 0.62 | 0.11 | 0.69 | 0.62 | -0.7 | 0.15 | - | 0.098 | 0.018 | |
KINASE-PSP_CDK5 | 0.03 | - | - | - | 2.0e-4 | -0.68 | 0.072 | - | - | -0.66 | 0.85 | |
HALLMARK_SPERMATOGENESIS | 0.033 | 0.92 | -0.4 | -0.69 | 6.5e-4 | 0.72 | 0.32 | 0.064 | - | 0.053 | -0.31 | |
cibersort: NK cell activated | 0.036 | -0.48 | 0.029 | 0.65 | 0.012 | 0.33 | 0.55 | -0.33 | - | 0.77 | 0.35 | |
cibersort: Mast cell resting | 0.079 | -0.49 | 0.29 | 0.51 | 0.3 | 0.77 | 0.53 | 0.13 | - | 0.21 | -0.65 | |
HALLMARK_PANCREAS_BETA_CELLS | 0.094 | 0.2 | 0.88 | 0.34 | 4.4e-3 | 0.97 | 0.7 | -0.54 | - | 0.84 | -0.82 | |
SBS4 (smoking) | 0.12 | - | - | - | - | -0.42 | 0.028 | 0.19 | - | - | - |
Cis-association
Associations between omics data of CNNM2
Trans-association
Associations of the protein abundance of CNNM2 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.