Basic information
- Full name
- dual specificity phosphatase 8
- Ensembl
- ENSG00000184545.11
- Summary
- The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]
- Annotation
- Phosphatase
Protein product
- ENST00000397374.8 Primary ENSP00000380530.3 (2 phosphosites)
- ENST00000331588.4
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -8.2e-15 | - | -2.2e-18 | - | - | 2.3e-5 | -1.5e-20 | -0.062 | - | -0.091 | - |
protein | - | - | - | - | - | - | - | - | - | - | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of DUSP8 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
cibersort: B cell naive | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: B cell memory | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: B cell plasma | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: T cell CD8+ | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: T cell CD4+ naive | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: T cell CD4+ memory resting | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: T cell CD4+ memory activated | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: T cell follicular helper | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: T cell regulatory (Tregs) | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: T cell gamma delta | - | - | - | - | - | - | - | - | - | - | - |
Cis-association
Associations between omics data of DUSP8
Trans-association
Associations of the protein abundance of DUSP8 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.