Basic information

Full name
5-hydroxytryptamine receptor 2A
Ensembl
ENSG00000102468.10
Summary
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Annotation
Druggable target (Tier T2) Receptor

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.5e-18--3.3e-15---6.6e-7-1.6e-3-1.6e-4-0.91-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910log2(RSEM+1)tumornormal
Protein expression
GBM1717.51818.51919.52020.52121.5log2(MS1 intensity)tumor

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820220-2-4-6-8-10-12-14-16-18-20-22Pan-cancer0102030405060700-10-20-30-40-50-60-70proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of HTR2A with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_PANCREAS_BETA_CELLS3.5e-5---3.5e-5------
HALLMARK_KRAS_SIGNALING_DN7.9e-5---7.9e-5------
DISEASE-PSP_Alzheimer's_disease1.7e-4---1.7e-4------
HALLMARK_HEDGEHOG_SIGNALING9.6e-4---9.6e-4------
KINASE-PSP_CDK52.7e-3---2.7e-3------
HALLMARK_SPERMATOGENESIS4.7e-3---4.7e-3------
Clinical: Tumor_Size_cm0.038---0.038------
xcell: Common myeloid progenitor0.04---0.04------
cibersort: B cell memory0.053---0.053------
xcell: T cell CD4+ (non-regulatory)0.1---0.1------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of HTR2A

BRCA0.12proteinmRNASCNVmethylationCCRCC-0.01proteinmRNASCNVmethylationCOAD-0.03proteinmRNASCNVmethylationGBM0.59-0.08-0.05proteinmRNASCNVmethylationHNSCC-0.06proteinmRNASCNVmethylationLSCC0.24proteinmRNASCNVmethylationLUAD0.21proteinmRNASCNVmethylationOV0.05proteinmRNASCNVmethylationPDAC-0.01proteinmRNASCNVmethylationUCEC0.15proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of HTR2A and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.