Basic information
- Full name
- lipoyltransferase 1
- Ensembl
- ENSG00000144182.17
- Summary
- The process of transferring lipoic acid to proteins is a two-step process. The first step is the activation of lipoic acid by lipoate-activating enzyme to form lipoyl-AMP. For the second step, the protein encoded by this gene transfers the lipoyl moiety to apoproteins. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 13. Read-through transcription also exists between this gene and the neighboring downstream mitochondrial ribosomal protein L30 (MRPL30) gene. [provided by RefSeq, Mar 2011]
Protein product
- ENST00000651691.1 Primary ENSP00000498546.1 (0 phosphosite)
- ENST00000393473.6
- ENST00000393471.2
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -0.004 | - | 0.17 | - | - | -1.9e-7 | -0.66 | -0.1 | - | -0.59 | - |
protein | -4e-20 | - | -1.7e-7 | - | - | - | -1.4e-11 | -8.6e-5 | - | - | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of LIPT1 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
KINASE-PSP_CAMK2A | 7.2e-4 | - | - | - | 7.2e-4 | - | - | - | - | - | - | |
HALLMARK_HEME_METABOLISM | 3.2e-3 | 0.15 | 0.29 | - | 0.069 | -0.29 | 8.9e-3 | -0.99 | 0.56 | - | 0.061 | |
cibersort: Eosinophil | 5.1e-3 | 0.12 | 0.26 | - | 0.29 | 0.15 | 0.85 | 0.28 | -0.7 | - | 0.06 | |
KINASE-PSP_PRKD1 | 6.5e-3 | - | - | - | 0.033 | - | - | - | 0.086 | - | - | |
xcell: Neutrophil | 6.8e-3 | 0.095 | 0.071 | - | -0.97 | 0.58 | 0.022 | 0.88 | -0.74 | - | 0.12 | |
HALLMARK_BILE_ACID_METABOLISM | 9.9e-3 | 0.26 | -0.91 | - | 0.095 | -0.36 | 7.6e-3 | 0.055 | 0.12 | - | -0.55 | |
HALLMARK_KRAS_SIGNALING_UP | 0.025 | 0.71 | 0.008 | - | 0.26 | -0.14 | 1 | 0.074 | 0.87 | - | 0.083 | |
KINASE-PSP_RSK2/RPS6KA3 | 0.032 | - | - | - | 0.032 | - | - | - | - | - | - | |
xcell: Monocyte | 0.033 | -0.95 | 0.035 | - | 0.28 | -0.72 | -0.86 | 0.72 | 0.66 | - | 8.6e-3 | |
cibersort: Mast cell resting | 0.034 | 0.19 | 3.4e-3 | - | -0.51 | 0.28 | 0.12 | -0.52 | -0.38 | - | 0.21 |
Cis-association
Associations between omics data of LIPT1
Trans-association
Associations of the protein abundance of LIPT1 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.