Basic information
- Full name
- chloride intracellular channel 5
- Ensembl
- ENSG00000112782.19
- Summary
- This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Protein product
- ENST00000185206.12 Primary ENSP00000185206.6 (3 phosphosites)
- ENST00000339561.12
- ENST00000644324.1
- ENST00000672327.1
- ENST00000544153.3
- ENST00000644878.1
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -2.8e-65 | - | -3.7e-27 | - | - | -1.5e-6 | -1.7e-34 | -6.2e-36 | - | 0.027 | - |
protein | -2e-60 | - | -1.2e-29 | -2e-8 | - | -2.9e-17 | -2.1e-35 | -4.8e-36 | 0.005 | -0.4 | 0.048 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of CLIC5 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_BILE_ACID_METABOLISM | 1.5e-12 | 0.14 | 7.8e-3 | 0.79 | 0.02 | 0.021 | 2.4e-3 | 0.011 | 0.088 | 0.12 | 7.6e-6 | |
xcell: Hematopoietic stem cell | 2.7e-11 | 7.8e-3 | 2.2e-3 | 0.88 | 0.18 | 1.3e-4 | 6.1e-8 | 4.5e-4 | -0.25 | 0.004 | -0.53 | |
PROGENy: Androgen | 3.8e-10 | 0.01 | 0.074 | -0.66 | 0.44 | 0.82 | 2.1e-5 | 6.8e-5 | -0.52 | 0.031 | 2.5e-7 | |
PROGENy: Trail | 1.8e-9 | 5.3e-4 | 0.1 | 0.74 | 0.075 | 2.6e-5 | 6.8e-8 | 0.11 | -0.004 | 0.3 | 0.015 | |
xcell: stroma score | 6e-9 | 4.4e-3 | 0.04 | -0.98 | -0.83 | 2.4e-5 | 2.8e-7 | 0.013 | -0.44 | 0.023 | 0.68 | |
xcell: Endothelial cell | 3.8e-8 | 0.017 | 0.1 | 0.84 | -0.86 | 6.8e-4 | 7.3e-13 | 0.048 | 0.43 | -0.77 | 0.76 | |
xcell: microenvironment score | 5.8e-8 | 4.6e-8 | 2.1e-3 | 0.96 | 0.96 | 3.1e-6 | 3.7e-8 | 0.18 | -0.083 | -0.64 | -0.43 | |
xcell: Cancer associated fibroblast | 2.2e-7 | 0.015 | 0.38 | -0.84 | 0.3 | 4.9e-4 | 3.3e-4 | 0.024 | 0.81 | 0.034 | 0.59 | |
HALLMARK_HEME_METABOLISM | 4e-7 | 0.061 | 0.005 | 0.61 | 0.49 | 7.9e-3 | 2.0e-4 | 0.056 | -0.42 | 0.21 | 0.16 | |
xcell: T cell CD8+ | 4.1e-6 | 5.5e-5 | 0.11 | 0.78 | 0.54 | 6.3e-6 | 9.6e-3 | 0.97 | -0.46 | 0.092 | -0.96 |
Cis-association
Associations between omics data of CLIC5
Trans-association
Associations of the protein abundance of CLIC5 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.