Basic information

Full name
ciliary neurotrophic factor receptor
Ensembl
ENSG00000122756.15
Summary
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]
Annotation
Receptor

Protein product

  • ENST00000378980.8 Primary ENSP00000368265.3 (0 phosphosite)
  • ENST00000610543.4
  • ENST00000351266.8
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-6.3e-88--2.1e-17---2.9e-21-1.9e-25-1.9e-31--1.1e-5-
protein-9.3e-44-----4.9e-11-2.4e-15-8.6e-13-1.1e-9--

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789101112log2(RSEM+1)tumornormal
Protein expression
BRCAGBMHNSCCLSCCLUADOVUCEC14151617181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14Pan-cancer0246810121416182022240-2-4-6-8-10-12-14-16-18-20-22-24proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CNTFR with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_HEDGEHOG_SIGNALING1.2e-50.027--0.01-0.440.650.321.6e-4-0.018
HALLMARK_KRAS_SIGNALING_DN0.0010.065--3.3e-5-0.45-0.640.60.54-5.6e-3
xcell: Hematopoietic stem cell1.3e-30.035--0.310.210.23-0.810.47-0.016
xcell: stroma score2.6e-37.9e-3---0.840.660.760.740.095-5.6e-3
xcell: Cancer associated fibroblast3.3e-30.002---0.340.530.590.680.2-5.6e-3
HALLMARK_PANCREAS_BETA_CELLS3.4e-30.75--5.2e-5-0.20.990.0180.41-0.14
PROGENy: TGFb4.4e-30.19---0.240.850.760.145.2e-3-8.2e-3
xcell: Endothelial cell4.8e-35.6e-4---0.870.510.710.27-0.91-0.03
Clinical: Age8.7e-3-0.2--0.120.190.094-0.536.7e-3-0.11
HALLMARK_TGF_BETA_SIGNALING9.2e-30.09---1.2e-30.42-0.740.189.8e-4-8.8e-4
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CNTFR

BRCA0.590.090.04proteinmRNASCNVmethylationCCRCC0.05proteinmRNASCNVmethylationCOAD-0.17proteinmRNASCNVmethylationGBM0.720.180.21proteinmRNASCNVmethylationHNSCC0.01-0.130.12proteinmRNASCNVmethylationLSCC0.440.110.23proteinmRNASCNVmethylationLUAD0.080.050.01proteinmRNASCNVmethylationOV0.430.270.44proteinmRNASCNVmethylationPDAC0.10proteinmRNASCNVmethylationUCEC0.550.190.04proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CNTFR and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.