Basic information

Full name
DnaJ heat shock protein family (Hsp40) member C24
Ensembl
ENSG00000170946.15
Summary
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]

Protein product

  • ENST00000465995.6 Primary ENSP00000417548.1 (0 phosphosite)
Phosphosites on the primary protein product
Loading...

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.18-0.16--1.4e-40.49-4.5e-3--0.94-
protein0.21-1.1e-11----0.001-8.3e-8--0.5-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADPDACUCEC14151617181920212223log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567890-1-2-3-4-5-6-7-8-9Pan-cancer02468101214160-2-4-6-8-10-12-14-16proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of DNAJC24 with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: stroma score2.5e-60.280.51-0.19-0.95.5e-40.036-0.0120.018
xcell: Cancer associated fibroblast4.5e-50.088-0.88-0.87-0.665.7e-40.055-0.0219.3e-3
PROGENy: TGFb5.0e-50.23-0.69-0.082-0.590.0020.33-0.0388.8e-4
cibersort: Macrophage M25.1e-50.110.049-0.480.430.240.11-0.0920.055
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION5.6e-50.281-0.29-0.60.0120.058-1.9e-30.024
HALLMARK_ANGIOGENESIS1.8e-40.1-0.77-0.1210.0570.048-0.120.12
xcell: Endothelial cell2.0e-40.0190.38-0.160.320.010.17--0.220.028
ESTIMATE: StromalScore2.8e-40.089-0.58-0.29-0.450.0060.027-0.0740.036
HALLMARK_UV_RESPONSE_DN3.3e-40.098-0.72-0.49-0.493.9e-30.13-0.0360.019
KINASE-PSP_PAK16.1e-4---0.3-0.915.5e-4--0.0880.12
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of DNAJC24

BRCA0.280.160.37proteinmRNASCNVmethylationCCRCC0.210.020.10-0.030.07-0.12proteinmRNASCNVmethylationCOAD0.23proteinmRNASCNVmethylationGBM0.23-0.270.220.050.31-0.09proteinmRNASCNVmethylationHNSCC0.21-0.07-0.10-0.090.55-0.27proteinmRNASCNVmethylationLSCC0.22-0.090.24-0.080.46-0.24proteinmRNASCNVmethylationLUAD0.09-0.03-0.09-0.040.41-0.33proteinmRNASCNVmethylationOV0.53proteinmRNASCNVmethylationPDAC0.27-0.150.04-0.010.230.01proteinmRNASCNVmethylationUCEC0.15-0.100.23-0.070.21-0.25proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of DNAJC24 and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.