Basic information
- Full name
- DnaJ heat shock protein family (Hsp40) member C24
- Ensembl
- ENSG00000170946.15
- Summary
- Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]
Protein product
- ENST00000465995.6 Primary ENSP00000417548.1 (0 phosphosite)
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 0.18 | - | 0.16 | - | - | 1.4e-4 | 0.49 | -4.5e-3 | - | -0.94 | - |
protein | 0.21 | - | 1.1e-11 | - | - | - | -0.001 | -8.3e-8 | - | -0.5 | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of DNAJC24 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
xcell: stroma score | 2.5e-6 | 0.28 | 0.51 | - | 0.19 | -0.9 | 5.5e-4 | 0.036 | - | 0.012 | 0.018 | |
xcell: Cancer associated fibroblast | 4.5e-5 | 0.088 | -0.88 | - | 0.87 | -0.66 | 5.7e-4 | 0.055 | - | 0.021 | 9.3e-3 | |
PROGENy: TGFb | 5.0e-5 | 0.23 | -0.69 | - | 0.082 | -0.59 | 0.002 | 0.33 | - | 0.038 | 8.8e-4 | |
cibersort: Macrophage M2 | 5.1e-5 | 0.11 | 0.049 | - | 0.48 | 0.43 | 0.24 | 0.11 | - | 0.092 | 0.055 | |
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION | 5.6e-5 | 0.28 | 1 | - | 0.29 | -0.6 | 0.012 | 0.058 | - | 1.9e-3 | 0.024 | |
HALLMARK_ANGIOGENESIS | 1.8e-4 | 0.1 | -0.77 | - | 0.12 | 1 | 0.057 | 0.048 | - | 0.12 | 0.12 | |
xcell: Endothelial cell | 2.0e-4 | 0.019 | 0.38 | - | 0.16 | 0.32 | 0.01 | 0.17 | - | -0.22 | 0.028 | |
ESTIMATE: StromalScore | 2.8e-4 | 0.089 | -0.58 | - | 0.29 | -0.45 | 0.006 | 0.027 | - | 0.074 | 0.036 | |
HALLMARK_UV_RESPONSE_DN | 3.3e-4 | 0.098 | -0.72 | - | 0.49 | -0.49 | 3.9e-3 | 0.13 | - | 0.036 | 0.019 | |
KINASE-PSP_PAK1 | 6.1e-4 | - | - | - | 0.3 | -0.91 | 5.5e-4 | - | - | 0.088 | 0.12 |
Cis-association
Associations between omics data of DNAJC24
Trans-association
Associations of the protein abundance of DNAJC24 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.