Basic information

Full name
integrin subunit alpha E
Ensembl
ENSG00000083457.12
Summary
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T4) Receptor

Protein product

  • ENST00000263087.9 Primary ENSP00000263087.4 (0 phosphosite)
Phosphosites on the primary protein product
Loading...

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.12-7.8e-6--1.4e-3-9.4e-9-2.3e-6--0.49-
protein0.81----0.033-1.2e-4-0.17-3.6e-4-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC5.566.577.588.599.51010.51111.512log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCHNSCCLSCCLUADOVPDACUCEC1415161718192021222324log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012141618200-2-4-6-8-10-12-14-16-18-20Pan-cancer01020304050607080900-10-20-30-40-50-60-70-80-90proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ITGAE with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_ALLOGRAFT_REJECTION4.9e-393.6e-3---2.2e-162.2e-162.6e-5-1.1e-44.0e-6
ESTIMATE: ImmuneScore1.1e-360.024---2.2e-162.2e-166.2e-4-3.5e-52.1e-6
xcell: Plasmacytoid dendritic cell5.3e-302.5e-3---8e-121.1e-124.5e-6-0.0111.7e-4
HALLMARK_INTERFERON_GAMMA_RESPONSE1.3e-270.011---1.1e-102.2e-161.2e-3-0.0591.4e-5
cibersort: T cell CD8+2e-272.5e-3---6.4e-113.5e-81.4e-9-0.091.8e-4
xcell: immune score5.1e-270.025---2.2e-167.4e-93.4e-3-2.7e-43.6e-4
xcell: T cell CD8+ central memory5.2e-254.6e-3---3.8e-129.1e-93.3e-8-0.0520.021
HALLMARK_IL6_JAK_STAT3_SIGNALING1e-240.1---2.2e-168.5e-86.6e-3-2.9e-32.2e-5
HALLMARK_COMPLEMENT1.6e-240.069---4.2e-133.4e-77.1e-3-6.2e-42.1e-6
cibersort: T cell CD4+ memory activated1e-233.5e-4---4e-72.3e-61.3e-6-4.2e-34.4e-4
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ITGAE

BRCA0.46-0.090.25proteinmRNASCNVmethylationCCRCC0.08proteinmRNASCNVmethylationCOAD0.44proteinmRNASCNVmethylationGBM0.37proteinmRNASCNVmethylationHNSCC0.730.030.29proteinmRNASCNVmethylationLSCC0.830.260.33proteinmRNASCNVmethylationLUAD0.650.060.38proteinmRNASCNVmethylationOV0.53proteinmRNASCNVmethylationPDAC0.390.270.32proteinmRNASCNVmethylationUCEC0.69-0.12-0.01proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ITGAE and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.