Basic information
- Full name
- diphosphoinositol pentakisphosphate kinase 1
- Ensembl
- ENSG00000168781.22
- Summary
- This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010]
- Annotation
- Phosphatase
Protein product
- ENST00000420765.5 Primary ENSP00000400887.1 (17 phosphosites)
- ENST00000396923.7
- ENST00000381885.5
- ENST00000381879.8
- ENST00000334933.8
- ENST00000360301.8
- ENST00000360135.8
- ENST00000348806.10
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 0.048 | - | -4.7e-19 | - | - | -3.3e-5 | 3.9e-17 | 7.8e-13 | - | 0.23 | - |
protein | -2.5e-8 | - | -0.046 | -4.1e-6 | - | -4.5e-6 | -2.9e-6 | -4.9e-5 | -0.48 | 0.41 | 5.1e-5 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of PPIP5K1 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_ESTROGEN_RESPONSE_LATE | 7.3e-8 | 4.3e-5 | 0.032 | 0.76 | 0.37 | 0.77 | 1.6e-3 | 0.74 | 0.16 | 0.11 | 4.7e-3 | |
PROGENy: p53 | 9.4e-7 | 0.11 | 0.34 | 0.61 | 0.018 | 0.27 | 5.8e-5 | 0.76 | -0.44 | 0.006 | 8.3e-3 | |
HALLMARK_ESTROGEN_RESPONSE_EARLY | 1.5e-6 | 3.5e-5 | 0.087 | -0.08 | 0.016 | 0.17 | 0.013 | 0.29 | 0.42 | 0.34 | 0.043 | |
HALLMARK_BILE_ACID_METABOLISM | 1.6e-4 | 0.027 | -0.41 | 0.69 | 3.2e-4 | -0.26 | -0.7 | 0.032 | 0.065 | 1.1e-3 | 0.4 | |
HALLMARK_PEROXISOME | 1.6e-4 | 0.13 | -0.69 | -0.75 | 0.084 | 0.17 | 0.48 | 0.35 | 0.051 | 3.2e-4 | 0.39 | |
HALLMARK_HEME_METABOLISM | 4.6e-4 | 0.15 | -0.81 | 0.75 | 4.0e-5 | -0.19 | 0.29 | 0.78 | 0.49 | 0.05 | 5.4e-3 | |
DISEASE-PSP_Alzheimer's_disease | 5.0e-4 | - | - | - | 6.2e-6 | - | - | - | - | - | 0.69 | |
HALLMARK_ADIPOGENESIS | 1.5e-3 | 0.06 | 0.87 | 0.53 | 0.052 | -0.16 | 0.59 | 0.22 | 0.1 | 0.067 | 0.11 | |
KINASE-PSP_CAMK2A | 1.9e-3 | - | - | - | 1.9e-3 | - | - | - | - | - | - | |
HALLMARK_XENOBIOTIC_METABOLISM | 2.2e-3 | 0.5 | 0.65 | 0.83 | 0.14 | -0.16 | -0.75 | 0.02 | 0.051 | 0.053 | 0.019 |
Cis-association
Associations between omics data of PPIP5K1
Trans-association
Associations of the protein abundance of PPIP5K1 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.