Basic information

Full name
diphosphoinositol pentakisphosphate kinase 1
Ensembl
ENSG00000168781.22
Summary
This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010]
Annotation
Phosphatase

Protein product

  • ENST00000420765.5 Primary ENSP00000400887.1 (17 phosphosites)
  • ENST00000396923.7
  • ENST00000381885.5
  • ENST00000381879.8
  • ENST00000334933.8
  • ENST00000360301.8
  • ENST00000360135.8
  • ENST00000348806.10
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.048--4.7e-19---3.3e-53.9e-177.8e-13-0.23-
protein-2.5e-8--0.046-4.1e-6--4.5e-6-2.9e-6-4.9e-5-0.480.415.1e-5

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.512log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC17.51818.51919.52020.52121.52222.52323.524log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567890-1-2-3-4-5-6-7-8-9Pan-cancer01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PPIP5K1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_ESTROGEN_RESPONSE_LATE7.3e-84.3e-50.0320.760.370.771.6e-30.740.160.114.7e-3
PROGENy: p539.4e-70.110.340.610.0180.275.8e-50.76-0.440.0068.3e-3
HALLMARK_ESTROGEN_RESPONSE_EARLY1.5e-63.5e-50.087-0.080.0160.170.0130.290.420.340.043
HALLMARK_BILE_ACID_METABOLISM1.6e-40.027-0.410.693.2e-4-0.26-0.70.0320.0651.1e-30.4
HALLMARK_PEROXISOME1.6e-40.13-0.69-0.750.0840.170.480.350.0513.2e-40.39
HALLMARK_HEME_METABOLISM4.6e-40.15-0.810.754.0e-5-0.190.290.780.490.055.4e-3
DISEASE-PSP_Alzheimer's_disease5.0e-4---6.2e-6-----0.69
HALLMARK_ADIPOGENESIS1.5e-30.060.870.530.052-0.160.590.220.10.0670.11
KINASE-PSP_CAMK2A1.9e-3---1.9e-3------
HALLMARK_XENOBIOTIC_METABOLISM2.2e-30.50.650.830.14-0.16-0.750.020.0510.0530.019
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PPIP5K1

BRCA0.670.280.33proteinmRNASCNVmethylationCCRCC0.280.110.16proteinmRNASCNVmethylationCOAD0.210.250.56proteinmRNASCNVmethylationGBM0.670.140.22proteinmRNASCNVmethylationHNSCC0.540.260.39proteinmRNASCNVmethylationLSCC0.660.320.38proteinmRNASCNVmethylationLUAD0.640.440.49proteinmRNASCNVmethylationOV0.510.410.55proteinmRNASCNVmethylationPDAC0.630.370.44proteinmRNASCNVmethylationUCEC0.550.160.33proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PPIP5K1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.