Basic information
- Full name
- translocase of inner mitochondrial membrane 22
- Ensembl
- ENSG00000177370.5
- Summary
- Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]
- Annotation
- Essential genes
Protein product
- ENST00000327158.5 Primary ENSP00000320236.2 (0 phosphosite)
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -1.1e-24 | - | -4.3e-9 | - | - | -0.17 | -5.9e-4 | -4e-13 | - | -5.4e-7 | - |
protein | -0.11 | - | -7.5e-16 | 0.85 | - | -0.45 | 0.14 | 7.3e-8 | -0.81 | -8.8e-6 | 0.048 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of TIMM22 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_OXIDATIVE_PHOSPHORYLATION | 6.5e-5 | 0.086 | 2.2e-3 | -0.43 | -0.85 | 0.16 | 0.39 | 0.07 | 0.16 | 0.16 | 0.051 | |
xcell: T cell CD4+ Th1 | 9.1e-5 | 0.13 | 0.49 | 0.13 | -0.67 | -0.51 | 0.017 | 0.045 | 0.15 | 6.7e-3 | 0.23 | |
Tumor Purity (ABSOLUTE) | 2.6e-3 | 3.8e-3 | 0.041 | 0.16 | -0.33 | 0.21 | 0.068 | -0.83 | 0.23 | -0.017 | 0.013 | |
HALLMARK_FATTY_ACID_METABOLISM | 2.6e-3 | 0.58 | 0.04 | -0.67 | -0.71 | 0.21 | 0.79 | 0.12 | 0.88 | 5.2e-3 | 0.094 | |
chromosomal instability | 4.7e-3 | 0.16 | 0.1 | 0.29 | -0.6 | 0.52 | 7.5e-3 | 0.036 | 0.42 | -0.2 | 0.68 | |
HALLMARK_PEROXISOME | 5.6e-3 | 0.015 | 0.024 | -0.41 | 0.66 | 0.92 | -0.46 | -0.5 | 0.12 | 0.05 | 0.024 | |
Tumor Purity (WGS) | 0.008 | - | 0.023 | - | -0.84 | 0.19 | 0.073 | 0.55 | - | -0.45 | 0.045 | |
HALLMARK_KRAS_SIGNALING_DN | 0.015 | 0.6 | -0.57 | 0.41 | 9.7e-4 | 0.43 | -0.99 | -0.89 | 0.59 | 4.8e-3 | -0.68 | |
HALLMARK_CHOLESTEROL_HOMEOSTASIS | 0.025 | -0.63 | 0.21 | -0.98 | -0.75 | 2.5e-3 | -0.4 | 0.14 | -0.41 | 0.087 | 0.036 | |
SMAD4 mutation | 0.027 | - | - | 0.072 | - | - | - | - | - | 0.19 | - |
Cis-association
Associations between omics data of TIMM22
Trans-association
Associations of the protein abundance of TIMM22 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.