Gene: TP53

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
tumor protein p53
Ensembl
ENSG00000141510.17
Summary
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Annotation
Cancer driver (Oncogene) Cancer driver (TSG) Transcription factor Druggable target (Tier T4)

Protein product

  • ENST00000269305.8 Primary ENSP00000269305.4 (9 phosphosites)
  • ENST00000445888.6
  • ENST00000504937.5
  • ENST00000619186.4
  • ENST00000504290.5
  • ENST00000510385.5
  • ENST00000610623.4
  • ENST00000618944.4
  • ENST00000615910.4
  • ENST00000610292.4
  • ENST00000620739.4
  • ENST00000619485.4
  • ENST00000455263.6
  • ENST00000359597.8
  • ENST00000617185.4
  • ENST00000420246.6
  • ENST00000610538.4
  • ENST00000622645.4
  • ENST00000413465.6
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA2.1e-17-1.2e-18---0.127.3e-54.5e-15--0.93-
protein2.1e-23-0.0058.2e-3-3.3e-61.6e-91.1e-50.341.0e-6-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC18192021222324252627log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14Pan-cancer024681012141618200-2-4-6-8-10-12-14-16-18-20proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TP53 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
TP53 mutation2.5e-219.2e-5-3.7e-31.3e-77.2e-3-8.4e-6--6.5e-5
HALLMARK_E2F_TARGETS2.6e-80.0810.450.150.440.0660.270.0150.0070.158.0e-4
KINASE-PSP_CDK14.1e-82.5e-4-0.38-0.960.0728.4e-30.229.5e-37.1e-30.61.6e-3
PERT-PSP_NOCODAZOLE5e-72.5e-40.980.770.330.0620.270.0150.020.822.9e-3
HALLMARK_G2M_CHECKPOINT6.6e-70.0710.520.360.970.0360.530.0142.3e-30.322.1e-3
SBS5 (unknown)1.6e-66.8e-30.13-0.990.130.110.0350.0270.30.320.14
KINASE-PSP_CDK28.0e-69.2e-4-0.54-0.890.340.0360.697.4e-30.0290.74.1e-3
HALLMARK_DNA_REPAIR8.5e-60.850.350.590.330.020.110.0280.280.582.2e-4
HALLMARK_MTORC1_SIGNALING1.1e-50.0110.48-0.850.460.460.0850.0110.220.34.5e-3
KINASE-PSP_ERK1/MAPK31.9e-50.0490.520.670.091-0.990.170.0140.0840.450.014
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TP53

BRCA0.380.000.32proteinmRNASCNVmethylationCCRCC-0.010.11-0.140.020.07-0.05proteinmRNASCNVmethylationCOAD0.22-0.440.22proteinmRNASCNVmethylationGBM0.200.03-0.01-0.080.180.16proteinmRNASCNVmethylationHNSCC0.720.110.040.010.260.16proteinmRNASCNVmethylationLSCC0.80-0.000.06-0.140.21-0.01proteinmRNASCNVmethylationLUAD0.360.13-0.05-0.100.21-0.03proteinmRNASCNVmethylationOV0.740.070.31proteinmRNASCNVmethylationPDAC0.52-0.04-0.010.110.31-0.18proteinmRNASCNVmethylationUCEC0.07-0.10-0.29-0.010.120.21proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TP53 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.