Basic information
- Phenotype
- KINASE-PSP_CDK1
- Description
- Enrichment score representing kinase activity of CDK1. The score was calculated using PTM-SEA on the phosphoproteomics data.
- Source
- https://proteomics.broadapps.org/ptmsigdb/
- Method
- Phosphosite signature scores were calculated using the PTMsigDB v1.9.0 database and the ssGSEA2.0 R package (PMID: 30563849). The parameters were the same as those used for Hallmark pathway activity (sample.norm.type="rank", weight=0.75, statistic="area.under.RES", nperm=1000, min.overlap=10). Phosphoproteomics data were filtered to the fifteenmer phosphosites with complete data across all samples within a cohort. If there were multiple rows with complete data for identical fifteenmers, one row was selected at random. Each site was z-score transformed. Activity scores are normalized enrichment scores from ssGSEA.
- Genes
-
- ADD1 S12
- ADD1 S355
- AHNAK S5763
- AJUBA S119
- ANAPC1 S688
- BRCA1 S1191
- BUB1B S543
- BUB1B S670
- BUB1B S1043
- CANX S583
- CDC16 S560
- CDC23 T562
- CDK7 T170
- CDK7 S164
- CDKN1A S130
- CREB1 S257
- CSNK2B S209
- CTTN S405
- CUEDC2 S110
- DLG1 S158
- DNM1L S616
- DNMT1 S154
- EEF1D S133
- EFHD2 S74
- EIF4EBP1 T70
- EIF4EBP1 S83
- EIF4G1 S1231
- EIF4G2 T508
- ELAVL1 S202
- EZH2 T487
- FLNA S1459
- FLNA S1084
- FLNA S1630
- FLNA S1533
- FOXK2 S428
- FOXK2 S373
- GIGYF2 S30
- H1-4 T18
- HMGA1 S36
- HMGA1 T53
- HNRNPK S216
- IRS2 S391
- KAT5 S86
- KAT5 S90
- KAT7 T85
- KIF11 T926
- KRT8 S432
- LATS1 S613
- LIG1 S76
- LIG3 S913
- LIG3 S210
- LMNA S390
- LMNA S22
- LMNA S392
- LMNB1 S23
- MAP2K1 T292
- MAP4 S787
- MAP4 S696
- MAP7 S209
- MEF2C S396
- NAGK S76
- NCKAP5L S440
- NCKAP5L S767
- NCL T121
- NCOA3 S728
- NIFK T238
- NME1 S120
- NPM1 S70
- NPM1 T199
- NSFL1C S140
- NUCKS1 S181
- NUMA1 T2015
- NUMA1 T2055
- NUP50 S221
- NUP98 T670
- NUP98 S623
- NUP98 S612
- NUP98 T546
- OGFR S378
- PAICS S27
- PALLD S641
- PIK3C2A S259
- PML S518
- PPP1CA T320
- PRC1 T481
- PTPN2 S304
- RAD9A S328
- RAP1GAP S484
- RB1 S807
- RB1 T373
- RB1 S249
- RCC1 S11
- RFC1 T506
- RNMT T77
- RPS3 T221
- RPS6KB1 S447
- RRM2 S20
- RSF1 S1375
- SAMHD1 T592
- SCML2 S511
- SIRT2 S368
- SLC9A3R1 S280
- SQSTM1 T269
- SQSTM1 S272
- SRRM2 T1413
- SRRM2 T866
- SSR1 S268
- STK3 S385
- STMN1 S38
- STMN1 S25
- SUPT5H S666
- TCOF1 T983
- TCOF1 S583
- TCOF1 S156
- TFPT S180
- TMPO S424
- TOP1 S112
- TOP2A S1213
- TOP2A S1247
- TOP2A S1393
- TOP2B S1424
- TP53 S315
- TP53BP1 S1678
- TPX2 S738
- U2AF2 S79
- UIMC1 S677
- USP16 S552
- USP24 S2604
- USP24 S2047
- VGLL4 S155
- VGLL4 S58
- VIM S56
- YAP1 S367
- YAP1 S289
- ZC3HC1 S395
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
| Signed p-values | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with KINASE-PSP_CDK1 to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
| Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with KINASE-PSP_CDK1 to WebGestalt.