Basic information
- Full name
- tRNA mitochondrial 2-thiouridylase
- Ensembl
- ENSG00000100416.15
- Summary
- This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Protein product
- ENST00000645190.1 Primary ENSP00000496496.1 (0 phosphosite)
- ENST00000381019.3
- ENST00000643137.1
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 1.4e-3 | - | -7.6e-4 | - | - | -0.13 | 1e-25 | 2.3e-13 | - | -4.8e-4 | - |
protein | -0.018 | - | -2.8e-26 | -6.4e-3 | - | 0.11 | 2.2e-10 | 0.4 | - | -1.7e-12 | 0.003 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of TRMU with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_MYC_TARGETS_V2 | 1.2e-6 | 3.8e-4 | 9.9e-3 | -0.38 | 0.81 | 5.9e-3 | 3.6e-4 | 8.5e-3 | -0.14 | 0.3 | 0.19 | |
chromosomal instability | 2.2e-5 | 0.062 | 1.9e-3 | 0.016 | 0.17 | 0.15 | 4.9e-4 | 0.12 | -0.34 | -0.33 | 0.92 | |
SBS5 (unknown) | 3.9e-5 | 1.8e-3 | 0.14 | 0.6 | 0.012 | 0.29 | 0.87 | 0.38 | 0.051 | 0.91 | 0.23 | |
HALLMARK_SPERMATOGENESIS | 1.6e-4 | 5.1e-5 | 0.82 | 0.96 | -0.57 | 0.12 | 9.4e-4 | 0.055 | -0.11 | 0.048 | 0.32 | |
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY | 1.6e-4 | 0.059 | 0.056 | 0.81 | 0.96 | 0.053 | 0.064 | 0.05 | 0.93 | 0.14 | 0.58 | |
KINASE-PSP_ERK2/MAPK1 | 2.9e-4 | 0.013 | 0.044 | 0.058 | -0.14 | 0.09 | 3.9e-5 | 0.19 | 0.16 | -0.046 | -0.98 | |
HALLMARK_UNFOLDED_PROTEIN_RESPONSE | 5.8e-4 | 2.6e-3 | 0.11 | 0.47 | 0.62 | 4.9e-3 | 0.058 | 5.2e-3 | -0.013 | -0.98 | 0.96 | |
HALLMARK_OXIDATIVE_PHOSPHORYLATION | 9.9e-4 | 0.27 | 0.51 | 0.82 | 0.4 | 0.024 | 0.074 | 0.021 | -0.24 | 0.048 | 0.67 | |
xcell: T cell CD4+ Th1 | 0.001 | 0.07 | -0.91 | -0.63 | 0.76 | 0.42 | 0.12 | 0.041 | 0.35 | 0.53 | 0.004 | |
PERT-PSP_NOCODAZOLE | 1.3e-3 | 2.0e-4 | 0.013 | -0.78 | -3.9e-3 | 0.044 | 1.2e-3 | 0.016 | -0.012 | 0.98 | 0.05 |
Cis-association
Associations between omics data of TRMU
Trans-association
Associations of the protein abundance of TRMU and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.