Protein: ENSP00000249504
Gene: HOXD11

LinkedOmicsKB © 2022-2023 Zhang Lab

HOXD11:
homeobox D11

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S223GAGGGGGSPCTKATP5322------36-541075444----9018
S241PKGAAEGSGGDGEGP61156-44--9-382244------222
Showing 1 to 2 of 2 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S223GAGGGGGSPCTKATP0.029-----9.3e-20----1.9e-9
S241PKGAAEGSGGDGEGP4.3e-11----4.3e-11-----
Showing 1 to 2 of 2 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PERT-PSP_UVS2414.3e-3----4.3e-3-----
xcell: Common lymphoid progenitorS2234.5e-3---0.31-0.11---0.021
SBS7b (UVR)S2415.9e-3----0.014----0.15
PROGENy: NFkBS2417.2e-3----0.076----0.043
CDKN2A mutationS2230.011-----0.011----
KINASE-PSP_GSK3BS2230.014---0.31-3.6e-3---0.74
xcell: T cell CD4+ Th1S2410.015----4.6e-3----0.54
PATH-NP_EGFR1_PATHWAYS2230.017---0.12-0.81---0.02
HALLMARK_G2M_CHECKPOINTS2410.02----5.6e-3----0.6
PROGENy: TNFaS2410.021----0.2----0.048
Showing 1 to 10 of 516 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS223S241proteinRNASCNVmethylationCCRCCS223S241proteinRNASCNVmethylationCOADS223S241proteinRNASCNVmethylationGBMS223S241proteinRNASCNVmethylationHNSCCS223S241proteinRNASCNVmethylationLSCCS223S241proteinRNASCNVmethylationLUADS223S241proteinRNASCNVmethylationOVS223S241proteinRNASCNVmethylationPDACS223S241proteinRNASCNVmethylationUCECS223S241proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
AKT3S2232.4e-6----0.86-0.89---2.2e-16
STK26S2233.8e-5---0.28-2.3e-3---2.6e-3
MAP3K20S2231.6e-4---0.29-0.85---1.2e-7
DYRK1AS2233.7e-4---0.038--0.25---1.7e-7
PAK2S2238.8e-4---0.056-3.8e-3---0.34
LRRK2S2411.4e-3----0.046----0.011
CILK1S2231.4e-3-----6.1e-4---0.28
CDK2S2411.8e-3----2.4e-4----0.46
ULK1S2230.003---0.41-4.7e-3---0.14
FERS2415.7e-3----0.2----8.3e-3
Showing 1 to 10 of 1076 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
GAKS241-9.6e-4-----0.1-----2.3e-3
PTPRES223-1.3e-3----0.042--2.4e-3----0.6
GAKS223-1.6e-3----0.042--0.21----0.027
ACP1S241-1.6e-3-----0.005-----0.099
TIGARS223-3.1e-3----0.037--0.08----0.2
UBASH3BS223-6.1e-3----0.26--0.021----0.19
NT5C2S223-9.3e-3----0.22--0.39----0.016
PTPN12S223-0.01----0.56--0.021----0.12
PTPRBS223-0.011----0.38--6.3e-3----
EYA2S241-0.011----------0.011
Showing 1 to 10 of 480 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.