Basic information
- Phenotype
- KINASE-PSP_GSK3B
- Description
- Enrichment score representing kinase activity of GSK3B. The score was calculated using PTM-SEA on the phosphoproteomics data.
- Source
- https://proteomics.broadapps.org/ptmsigdb/
- Method
- Phosphosite signature scores were calculated using the PTMsigDB v1.9.0 database and the ssGSEA2.0 R package (PMID: 30563849). The parameters were the same as those used for Hallmark pathway activity (sample.norm.type="rank", weight=0.75, statistic="area.under.RES", nperm=1000, min.overlap=10). Phosphoproteomics data were filtered to the fifteenmer phosphosites with complete data across all samples within a cohort. If there were multiple rows with complete data for identical fifteenmers, one row was selected at random. Each site was z-score transformed. Activity scores are normalized enrichment scores from ssGSEA.
- Genes
-
- ADD2 S693
- BCLAF1 S531
- CCND2 T280
- DPYSL2 T514
- DPYSL2 T509
- DPYSL3 T509
- DPYSL3 T514
- DPYSL3 S518
- DROSHA S302
- EIF4EBP1 T70
- EIF4EBP1 S65
- EZH2 T367
- FBXO4 S12
- FOXL2 S33
- GYS1 S653
- GYS1 S645
- HNRNPD S83
- HSF1 S303
- JUN S243
- JUNB T255
- KAT5 S90
- KAT5 S86
- KLC2 S608
- LRP6 S1490
- MYLK S1776
- NEFH S503
- NFKB2 S222
- PRKCE S346
- PSEN1 S357
- RELB S573
- RPTOR S722
- RPTOR S863
- SFPQ T687
- UNG T60
- USF2 T230
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
| Signed p-values | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with KINASE-PSP_GSK3B to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
| Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with KINASE-PSP_GSK3B to WebGestalt.