Protein: ENSP00000362978
Gene: EYA3

LinkedOmicsKB © 2022-2023 Zhang Lab

EYA3:
EYA transcriptional coactivator and phosphatase 3

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S64TDYIPRSSNDYTSQM514517-------5424221212----3514
S69RSSNDYTSQMYSAKP199-------------------
S255APAAQRLSSGDPSTS6420--2220----522760524944--1266016
S256PAAQRLSSGDPSTSP214----------------626-
S262SSGDPSTSPSLSQTT71479-3928----6455--622110102
S264GDPSTSPSLSQTTPS234--124----117----------
S266PSTSPSLSQTTPSKD3238-33--------45------
T268TSPSLSQTTPSKDTD62256-------543429253328--52-9
T269SPSLSQTTPSKDTDD6187------44-5455--22293799
S296KRKADATSSQDSELE19------------54------
Showing 1 to 10 of 12 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S64TDYIPRSSNDYTSQM0.24-----0.093----0.99
S69RSSNDYTSQMYSAKP-----------
S255APAAQRLSSGDPSTS-1.2e-8--0.45---0.43-2.6e-10-2.7e-10--0.15
S256PAAQRLSSGDPSTSP-----------
S262SSGDPSTSPSLSQTT-0.073--0.61-------0.043-
S264GDPSTSPSLSQTTPS-----------
S266PSTSPSLSQTTPSKD-----------
T268TSPSLSQTTPSKDTD3.6e-25----1.3e-92.1e-103.3e-8---
T269SPSLSQTTPSKDTDD-----------
S296KRKADATSSQDSELE-----------
Showing 1 to 10 of 12 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_E2F_TARGETSS4387.1e-222.2e-160.39-0.0891.4e-56.5e-32.0e-40.811.9e-49.4e-4
HALLMARK_G2M_CHECKPOINTS4389.4e-212.2e-160.5-0.0292.1e-41.4e-32.6e-40.630.0024.5e-3
KINASE-PSP_CDK1S4381.4e-207.8e-80.18-3.6e-56.7e-80.231.1e-30.291.2e-30.004
KINASE-PSP_CDK2S4386e-197.7e-88.7e-3-0.0167.6e-90.121.5e-4-0.589.1e-31.9e-3
HALLMARK_G2M_CHECKPOINTT2689.2e-18----2.5e-71.5e-69.7e-7---
HALLMARK_E2F_TARGETST2681.1e-17----4.4e-71.1e-68.5e-7---
PERT-PSP_NOCODAZOLES4383.6e-163.4e-70.016-2.4e-33.3e-50.0555.2e-5-0.190.010.012
HALLMARK_MYC_TARGETS_V2S4387.5e-162.0e-60.092-0.248.9e-91.9e-43.1e-30.960.224.4e-3
HALLMARK_DNA_REPAIRS4382.4e-142.1e-30.12-0.0277.9e-99.3e-47.9e-30.470.20.023
HALLMARK_E2F_TARGETST2693.6e-13---1.4e-3---0.23-2.2e-16
Showing 1 to 10 of 3096 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS64S69S255S256S262S264S266T268T269S296S297S438proteinRNASCNVmethylationCCRCCS64S69S255S256S262S264S266T268T269S296S297S438proteinRNASCNVmethylationCOADS64S69S255S256S262S264S266T268T269S296S297S438proteinRNASCNVmethylationGBMS64S69S255S256S262S264S266T268T269S296S297S438proteinRNASCNVmethylationHNSCCS64S69S255S256S262S264S266T268T269S296S297S438proteinRNASCNVmethylationLSCCS64S69S255S256S262S264S266T268T269S296S297S438proteinRNASCNVmethylationLUADS64S69S255S256S262S264S266T268T269S296S297S438proteinRNASCNVmethylationOVS64S69S255S256S262S264S266T268T269S296S297S438proteinRNASCNVmethylationPDACS64S69S255S256S262S264S266T268T269S296S297S438proteinRNASCNVmethylationUCECS64S69S255S256S262S264S266T268T269S296S297S438proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.