Gene: EPHA10

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
EPH receptor A10
Ensembl
ENSG00000183317.17
Summary
Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]
Annotation
Druggable target (Tier T4) Protein Kinase Receptor

Protein product

  • ENST00000373048.9 Primary ENSP00000362139.4 (0 phosphosite)
  • ENST00000427468.6
  • ENST00000319637.6
  • ENST00000540011.2
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.2e-5-0.26---3.9e-30.548.6e-21-0.12-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC123456789101112log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789100-1-2-3-4-5-6-7-8-9-10Pan-cancer02468101214160-2-4-6-8-10-12-14-16proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of EPHA10 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: B cell naive-----------
cibersort: T cell CD4+ memory activated-----------
cibersort: Monocyte-----------
cibersort: Macrophage M0-----------
cibersort: Macrophage M1-----------
cibersort: Macrophage M2-----------
cibersort: Myeloid dendritic cell resting-----------
cibersort: Mast cell resting-----------
xcell: Myeloid dendritic cell activated-----------
xcell: B cell-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of EPHA10

BRCA0.02proteinmRNASCNVmethylationCCRCC0.190.050.06proteinmRNASCNVmethylationCOAD0.18proteinmRNASCNVmethylationGBM-0.19-0.070.08proteinmRNASCNVmethylationHNSCC-0.18-0.210.08proteinmRNASCNVmethylationLSCC-0.040.13-0.01proteinmRNASCNVmethylationLUAD0.310.410.04proteinmRNASCNVmethylationOV0.14proteinmRNASCNVmethylationPDAC0.380.350.14proteinmRNASCNVmethylationUCEC0.170.18-0.13proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of EPHA10 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.