Basic information
- Full name
- erb-b2 receptor tyrosine kinase 4
- Ensembl
- ENSG00000178568.15
- Summary
- This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
- Annotation
- Cancer driver (Oncogene) Cancer driver (TSG) Druggable target (Tier T1) Protein Kinase Receptor
Protein product
- ENST00000342788.9 Primary ENSP00000342235.4 (6 phosphosites)
- ENST00000436443.5
- ENST00000402597.6
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -2.9e-96 | - | -2.6e-29 | - | - | -7.7e-13 | -8.8e-32 | -4.1e-25 | - | -1.3e-9 | - |
protein | -6.6e-3 | - | - | - | - | -0.16 | -2.1e-3 | - | -0.83 | - | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of ERBB4 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_BILE_ACID_METABOLISM | 3.0e-5 | 1.6e-4 | - | - | 0.02 | 0.31 | 0.26 | - | 0.087 | - | 0.77 | |
HALLMARK_HEME_METABOLISM | 2.1e-3 | 0.012 | - | - | 6.8e-3 | 0.14 | 0.059 | - | -0.55 | - | -0.65 | |
HALLMARK_PANCREAS_BETA_CELLS | 0.003 | 4.5e-4 | - | - | 0.12 | 0.55 | -0.9 | - | 0.54 | - | 0.26 | |
HALLMARK_PEROXISOME | 9.7e-3 | 4.8e-4 | - | - | 0.57 | 0.63 | 0.59 | - | 0.12 | - | -0.77 | |
cibersort: T cell CD4+ naive | 0.011 | - | - | - | 0.15 | 0.79 | - | - | 0.088 | - | 0.1 | |
PROGENy: Estrogen | 0.011 | 2.7e-10 | - | - | 0.42 | -0.3 | -0.12 | - | 0.17 | - | 0.78 | |
KINASE-PSP_P38A/MAPK14 | 0.012 | - | - | - | 0.044 | 0.16 | 0.59 | - | - | - | 0.28 | |
cibersort: Mast cell activated | 0.013 | 7.8e-6 | - | - | 0.89 | 0.025 | 0.034 | - | -0.5 | - | -0.03 | |
HALLMARK_ESTROGEN_RESPONSE_EARLY | 0.013 | 4.5e-7 | - | - | 0.93 | 0.71 | 0.42 | - | -0.31 | - | 0.44 | |
xcell: Neutrophil | 0.022 | 0.16 | - | - | 0.63 | -0.98 | 0.092 | - | 0.8 | - | 0.072 |
Cis-association
Associations between omics data of ERBB4
Trans-association
Associations of the protein abundance of ERBB4 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.