Basic information
- Phenotype
- KINASE-PSP_P38A/MAPK14
- Description
- Enrichment score representing kinase activity of p38alpha. The score was calculated using PTM-SEA on the phosphoproteomics data.
- Source
- https://proteomics.broadapps.org/ptmsigdb/
- Method
- Phosphosite signature scores were calculated using the PTMsigDB v1.9.0 database and the ssGSEA2.0 R package (PMID: 30563849). The parameters were the same as those used for Hallmark pathway activity (sample.norm.type="rank", weight=0.75, statistic="area.under.RES", nperm=1000, min.overlap=10). Phosphoproteomics data were filtered to the fifteenmer phosphosites with complete data across all samples within a cohort. If there were multiple rows with complete data for identical fifteenmers, one row was selected at random. Each site was z-score transformed. Activity scores are normalized enrichment scores from ssGSEA.
- Genes
-
- CCND2 T280
- CDKN1A S130
- CRYAB S59
- DROSHA S355
- EGFR S1039
- EGFR T693
- EPS15 S796
- EZH2 T367
- F3 S285
- FOXO3 S294
- GJA1 S279
- GSK3B T390
- HNF4A S167
- HSF1 S303
- HSF1 S307
- HSPB1 S176
- KAT5 T158
- KCNQ2 S466
- MEF2A S492
- MEF2A S406
- NCF1 S348
- NCF1 S345
- PXN S85
- RB1 S249
- S100A9 T113
- STAT1 S727
- STAT3 S727
- TWIST1 S68
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
| Signed p-values | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with KINASE-PSP_P38A/MAPK14 to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
| Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with KINASE-PSP_P38A/MAPK14 to WebGestalt.