Gene: GIT2

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
GIT ArfGAP 2
Ensembl
ENSG00000139436.21
Summary
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]

Protein product

  • ENST00000355312.8 Primary ENSP00000347464.3 (55 phosphosites)
  • ENST00000361006.9
  • ENST00000551209.5
  • ENST00000354574.8
  • ENST00000457474.6
  • ENST00000553118.5
  • ENST00000547815.5
  • ENST00000320063.10
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA7.6e-3-4.8e-29--0.014-2e-14-1.7e-4--1.6e-7-
protein-4.0e-5-6.1e-31-1.6e-12-4.9e-3-1.6e-18-9.7e-9-0.0569.9e-3-0.085

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC88.599.51010.51111.51212.51313.514log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2323.52424.52525.52626.527log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820220-2-4-6-8-10-12-14-16-18-20-22Pan-cancer0102030405060700-10-20-30-40-50-60-70proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of GIT2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: ESTIMATEScore4e-782e-8-0.312.2e-161.2e-32.2e-162.2e-162.2e-166.8e-71e-72.2e-16
xcell: microenvironment score2.6e-714e-8-0.747.9e-107.2e-42.2e-162.2e-162.2e-163.6e-51.5e-62.2e-16
ESTIMATE: StromalScore4.4e-627.4e-6-0.111.9e-96.2e-32.2e-162.2e-162.6e-91.7e-62.2e-82.2e-16
ESTIMATE: ImmuneScore6.8e-551.3e-6-0.771.3e-83.6e-42.2e-162.2e-162.2e-164.2e-52.9e-41.4e-3
HALLMARK_ALLOGRAFT_REJECTION4.7e-481.0e-4-0.561.3e-71.0e-42.2e-162.2e-162.2e-161.6e-45.7e-40.083
xcell: immune score8e-454.1e-4-0.454.9e-70.0012.2e-162.2e-162.2e-164.6e-32.5e-40.027
PROGENy: Trail1.1e-442.1e-60.471.6e-6-0.522.2e-162.2e-162.1e-95.4e-64.7e-52.1e-4
HALLMARK_IL2_STAT5_SIGNALING1.2e-435.1e-50.961.6e-77.6e-42.2e-162.2e-165.4e-93.6e-40.023.1e-3
HALLMARK_KRAS_SIGNALING_UP1.7e-413.9e-4-0.0641.8e-77.2e-32.2e-162.2e-162.6e-63.0e-42.3e-54.2e-5
xcell: T cell CD8+ central memory6.6e-416.2e-60.349.5e-60.0148.3e-136.6e-134.4e-130.0161.1e-36.1e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of GIT2

BRCA0.480.230.46proteinmRNASCNVmethylationCCRCC0.610.13-0.090.100.220.03proteinmRNASCNVmethylationCOAD0.310.040.22proteinmRNASCNVmethylationGBM0.59-0.090.32-0.080.350.04proteinmRNASCNVmethylationHNSCC0.71-0.01-0.010.020.27-0.06proteinmRNASCNVmethylationLSCC0.57-0.15-0.22-0.050.24-0.09proteinmRNASCNVmethylationLUAD0.41-0.080.060.030.500.03proteinmRNASCNVmethylationOV0.26-0.040.27proteinmRNASCNVmethylationPDAC0.31-0.03-0.05-0.120.39-0.09proteinmRNASCNVmethylationUCEC0.68-0.300.06-0.280.18-0.02proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of GIT2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.