Basic information

Full name
MAX dimerization protein 1
Ensembl
ENSG00000059728.11
Summary
This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Annotation
Transcription factor

Protein product

  • ENST00000264444.7 Primary ENSP00000264444.2 (0 phosphosite)
  • ENST00000540449.5
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.046-3.9e-7---7.1e-87.3e-4-1.0e-4-1.3e-7-
protein2.1e-4-----2.1e-4----

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC7.588.599.51010.51111.51212.51313.51414.5log2(RSEM+1)tumornormal
Protein expression
LSCCPDAC111213141516171819log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416180-2-4-6-8-10-12-14-16-18Pan-cancer05101520253035404550550-5-10-15-20-25-30-35-40-45-50-55proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of MXD1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: T cell CD4+ central memory5.4e-3-----6.5e-3--0.23-
HALLMARK_E2F_TARGETS7.1e-3-----0.035--0.089-
cibersort: NK cell activated9.3e-3-----0.01--0.27-
HALLMARK_MYC_TARGETS_V10.01-----8.7e-3--0.31-
KINASE-PSP_CDK10.016-----0.13--0.056-
cibersort: Neutrophil0.018-----0.75--2.4e-3-
PROGENy: NFkB0.022-----0.87--2.2e-3-
SBS1 (clock-like)0.022-----0.031--0.28-
KINASE-PSP_ERK1/MAPK30.023-----0.76--3.6e-3-
KINASE-PSP_CK2A1/CSNK2A10.025-----0.14--0.094-
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of MXD1

BRCA0.22proteinmRNASCNVmethylationCCRCC-0.160.19-0.16proteinmRNASCNVmethylationCOAD-0.07proteinmRNASCNVmethylationGBM-0.090.16-0.10proteinmRNASCNVmethylationHNSCC0.06-0.110.08proteinmRNASCNVmethylationLSCC0.490.130.290.08-0.100.07proteinmRNASCNVmethylationLUAD-0.130.35-0.06proteinmRNASCNVmethylationOV0.25proteinmRNASCNVmethylationPDAC0.740.33-0.160.020.230.06proteinmRNASCNVmethylationUCEC0.100.20-0.07proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of MXD1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.