Gene: NR6A1

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
nuclear receptor subfamily 6 group A member 1
Ensembl
ENSG00000148200.17
Summary
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]
Annotation
Transcription factor Druggable target (Tier T4)

Protein product

  • ENST00000487099.7 Primary ENSP00000420267.1 (0 phosphosite)
  • ENST00000344523.8
  • ENST00000373584.7
  • ENST00000416460.6
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-2.3e-21--6.5e-28---0.1-3.8e-3-0.021--6.1e-4-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC234567891011log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910110-1-2-3-4-5-6-7-8-9-10-11Pan-cancer01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of NR6A1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION-----------
HALLMARK_XENOBIOTIC_METABOLISM-----------
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY-----------
HALLMARK_UV_RESPONSE_UP-----------
HALLMARK_ANGIOGENESIS-----------
HALLMARK_HEME_METABOLISM-----------
HALLMARK_COAGULATION-----------
HALLMARK_IL2_STAT5_SIGNALING-----------
HALLMARK_PEROXISOME-----------
SBS5 (unknown)-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of NR6A1

BRCA0.07proteinmRNASCNVmethylationCCRCC-0.190.17-0.20proteinmRNASCNVmethylationCOAD0.19proteinmRNASCNVmethylationGBM0.190.120.06proteinmRNASCNVmethylationHNSCC-0.150.400.04proteinmRNASCNVmethylationLSCC0.070.400.19proteinmRNASCNVmethylationLUAD0.200.17-0.06proteinmRNASCNVmethylationOV0.39proteinmRNASCNVmethylationPDAC-0.030.340.09proteinmRNASCNVmethylationUCEC-0.09-0.120.09proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of NR6A1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.