Gene: PPM1K

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
protein phosphatase, Mg2+/Mn2+ dependent 1K
Ensembl
ENSG00000163644.15
Summary
This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]
Annotation
Phosphatase

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-9.2e-64--1.1e-27---5.3e-9-2.7e-19-2.5e-17--4.5e-4-
protein-1.1e-89--5.7e-30---1.4e-14-2.5e-24-1.6e-16-2.2e-4-3.4e-18-1.2e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC66.577.588.599.51010.51111.51212.513log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADOVPDACUCEC1818.51919.52020.52121.52222.52323.52424.525log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012141618202224260-2-4-6-8-10-12-14-16-18-20-22-24-26Pan-cancer051015202530354045500-5-10-15-20-25-30-35-40-45-50proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PPM1K with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: microenvironment score1.2e-309.3e-70.23-0.922.2e-162.2e-163.3e-52.8e-3-0.931.2e-6
ESTIMATE: ImmuneScore7.7e-204.3e-50.2-0.759.3e-82.2e-160.0060.0120.290.069
HALLMARK_IL2_STAT5_SIGNALING1.1e-181.1e-30.015--0.634.1e-62.2e-160.0870.0580.0543.6e-3
ESTIMATE: ESTIMATEScore1.4e-188.0e-50.56-0.693.6e-62.2e-160.0640.0390.215.4e-4
xcell: immune score9e-187.5e-40.4-0.952.6e-92.2e-162.8e-40.039-0.90.08
PROGENy: Trail1.2e-178.2e-50.76-0.0299.7e-96.7e-100.0380.040.540.01
xcell: T cell CD8+ central memory1.7e-161.4e-40.41-0.651.9e-63.5e-91.6e-40.0250.760.008
HALLMARK_ALLOGRAFT_REJECTION4.1e-151.5e-40.24--0.645.4e-72.2e-160.0740.0240.50.26
xcell: B cell plasma5.8e-150.021-0.85-0.36.6e-122.2e-160.0260.220.330.44
xcell: B cell memory7.1e-153.3e-30.63-0.654.2e-116.9e-120.050.0720.240.28
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PPM1K

BRCA0.670.160.02proteinmRNASCNVmethylationCCRCC0.260.130.270.080.09-0.06proteinmRNASCNVmethylationCOAD0.17proteinmRNASCNVmethylationGBM0.75-0.100.08-0.05-0.01-0.11proteinmRNASCNVmethylationHNSCC0.660.040.060.010.16-0.35proteinmRNASCNVmethylationLSCC0.71-0.150.30-0.180.37-0.44proteinmRNASCNVmethylationLUAD0.43-0.060.21-0.060.21-0.20proteinmRNASCNVmethylationOV0.510.330.58proteinmRNASCNVmethylationPDAC0.42-0.070.01-0.190.00-0.02proteinmRNASCNVmethylationUCEC0.550.01-0.05-0.210.060.05proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PPM1K and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.