Basic information
- Full name
- protein tyrosine kinase 7 (inactive)
- Ensembl
- ENSG00000112655.16
- Summary
- This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
- Annotation
- Druggable target (Tier T4) Protein Kinase Receptor
Protein product
- ENST00000230419.9 Primary ENSP00000230419.4 (9 phosphosites)
- ENST00000481273.5
- ENST00000345201.6
- ENST00000352931.6
- ENST00000349241.6
- ENST00000471863.5
- ENST00000476760.1
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 2.8e-23 | - | -4.4e-13 | - | - | 7e-21 | 2.6e-16 | 6e-20 | - | 5.8e-3 | - |
protein | 1.3e-26 | - | -2.8e-13 | 8.8e-12 | - | 8.4e-25 | 1.3e-20 | 2.7e-11 | 0.016 | 3e-14 | -2.6e-8 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of PTK7 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
PROGENy: TGFb | 1.6e-50 | 1.4e-10 | 3.0e-6 | 4e-8 | -0.42 | 1e-7 | 6.1e-4 | 8.3e-4 | 2.2e-16 | 2.2e-16 | 2.7e-3 | |
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION | 1.3e-45 | 2.2e-16 | 2.4e-7 | 6.9e-7 | 0.58 | 9.8e-7 | 9.8e-3 | 0.031 | 2.2e-16 | 8.8e-14 | 0.52 | |
HALLMARK_WNT_BETA_CATENIN_SIGNALING | 4.8e-25 | 4.5e-3 | 1.0e-4 | 0.01 | 0.3 | 4.8e-5 | 2.6e-4 | 0.23 | 0.017 | 3.8e-7 | 2.4e-9 | |
HALLMARK_TGF_BETA_SIGNALING | 7.9e-24 | 1.2e-5 | 1.9e-3 | 8.2e-6 | -0.88 | 1.4e-6 | 0.031 | 0.75 | 1.1e-8 | 4.9e-5 | 3.1e-3 | |
PROGENy: WNT | 7.6e-23 | 3.0e-5 | 1.0e-4 | 3.1e-6 | 0.047 | 0.1 | 0.42 | 0.62 | 1.8e-5 | 2.5e-6 | 7.4e-6 | |
HALLMARK_APICAL_JUNCTION | 7.9e-23 | 4.4e-6 | 5.8e-7 | 5.0e-4 | -0.47 | 6.3e-3 | 0.034 | 0.014 | 1.5e-8 | 4.3e-7 | 0.46 | |
HALLMARK_UV_RESPONSE_DN | 8.4e-23 | 3.4e-4 | 5.8e-8 | 9.0e-5 | 0.39 | 1.3e-3 | 9.3e-3 | 0.039 | 2.8e-6 | 3.7e-3 | 0.067 | |
HALLMARK_NOTCH_SIGNALING | 4.6e-20 | 2.5e-6 | 1.5e-4 | 0.1 | 0.3 | 2.2e-16 | 0.09 | 0.37 | 0.028 | 2.5e-3 | 0.069 | |
PROGENy: Hypoxia | 2.2e-16 | 2.2e-9 | 0.076 | 4.5e-5 | 0.35 | 5.7e-3 | 4.0e-4 | 0.49 | 0.01 | 9.0e-6 | -0.42 | |
HALLMARK_ANGIOGENESIS | 3.5e-16 | 1.9e-3 | 0.004 | 1.5e-8 | 0.59 | 1.3e-3 | 0.2 | 0.22 | 2.8e-6 | 0.079 | 0.14 |
Cis-association
Associations between omics data of PTK7
Trans-association
Associations of the protein abundance of PTK7 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.