Basic information

Full name
protein tyrosine kinase 7 (inactive)
Ensembl
ENSG00000112655.16
Summary
This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Annotation
Druggable target (Tier T4) Protein Kinase Receptor

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA2.8e-23--4.4e-13--7e-212.6e-166e-20-5.8e-3-
protein1.3e-26--2.8e-138.8e-12-8.4e-251.3e-202.7e-110.0163e-14-2.6e-8

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC56789101112131415log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC21.52222.52323.52424.52525.52626.52727.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer05101520253035404550550-5-10-15-20-25-30-35-40-45-50-55proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PTK7 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: TGFb1.6e-501.4e-103.0e-64e-8-0.421e-76.1e-48.3e-42.2e-162.2e-162.7e-3
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION1.3e-452.2e-162.4e-76.9e-70.589.8e-79.8e-30.0312.2e-168.8e-140.52
HALLMARK_WNT_BETA_CATENIN_SIGNALING4.8e-254.5e-31.0e-40.010.34.8e-52.6e-40.230.0173.8e-72.4e-9
HALLMARK_TGF_BETA_SIGNALING7.9e-241.2e-51.9e-38.2e-6-0.881.4e-60.0310.751.1e-84.9e-53.1e-3
PROGENy: WNT7.6e-233.0e-51.0e-43.1e-60.0470.10.420.621.8e-52.5e-67.4e-6
HALLMARK_APICAL_JUNCTION7.9e-234.4e-65.8e-75.0e-4-0.476.3e-30.0340.0141.5e-84.3e-70.46
HALLMARK_UV_RESPONSE_DN8.4e-233.4e-45.8e-89.0e-50.391.3e-39.3e-30.0392.8e-63.7e-30.067
HALLMARK_NOTCH_SIGNALING4.6e-202.5e-61.5e-40.10.32.2e-160.090.370.0282.5e-30.069
PROGENy: Hypoxia2.2e-162.2e-90.0764.5e-50.355.7e-34.0e-40.490.019.0e-6-0.42
HALLMARK_ANGIOGENESIS3.5e-161.9e-30.0041.5e-80.591.3e-30.20.222.8e-60.0790.14
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PTK7

BRCA0.720.060.24proteinmRNASCNVmethylationCCRCC0.87-0.090.25-0.150.23-0.27proteinmRNASCNVmethylationCOAD0.790.230.41proteinmRNASCNVmethylationGBM0.62-0.110.050.040.00-0.02proteinmRNASCNVmethylationHNSCC0.84-0.210.18-0.230.27-0.46proteinmRNASCNVmethylationLSCC0.870.000.250.030.31-0.19proteinmRNASCNVmethylationLUAD0.64-0.030.18-0.020.34-0.19proteinmRNASCNVmethylationOV0.700.430.58proteinmRNASCNVmethylationPDAC0.85-0.03-0.04-0.11-0.07-0.01proteinmRNASCNVmethylationUCEC0.71-0.120.00-0.080.11-0.00proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PTK7 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.