Basic information

Full name
TNF receptor superfamily member 21
Ensembl
ENSG00000146072.6
Summary
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
Annotation
Druggable target (Tier T5) Receptor

Protein product

Phosphosites on the primary protein product
Loading...

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA7.7e-32--9.7e-11--1.5e-97.4e-212.1e-31-1.5e-8-
protein4.6e-50----3.6e-62.1e-225.5e-15-3.7e-14-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC567891011121314log2(RSEM+1)tumornormal
Protein expression
BRCAGBMHNSCCLSCCLUADPDACUCEC15161718192021222324log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14Pan-cancer02468101214161820220-2-4-6-8-10-12-14-16-18-20-22proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TNFRSF21 with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: PI3K4.4e-60.21---0.142.8e-31.1e-31.6e-3-3.4e-30.96
PROGENy: TNFa6.7e-60.025---0.060.0157.0e-40.028-1.8e-4-0.83
KINASE-PSP_ERK1/MAPK38.9e-63.7e-4--0.390.330.0951.3e-3-0.05-0.62
HALLMARK_GLYCOLYSIS3.6e-50.36---6.8e-30.630.0626.7e-7-1.7e-50.27
PROGENy: NFkB7.3e-50.025---0.0340.0429.3e-40.069-2.6e-30.85
HALLMARK_ANGIOGENESIS1.3e-40.81---0.390.0975.5e-42.8e-4-9.5e-3-0.57
cibersort: Macrophage M01.8e-40.23--0.22-0.970.995.6e-4-1.1e-30.41
HALLMARK_INFLAMMATORY_RESPONSE4.0e-40.024---0.0870.27.8e-40.11-0.0450.56
HALLMARK_TNFA_SIGNALING_VIA_NFKB5.3e-40.032---0.0180.0284.6e-30.11-1.7e-3-0.71
xcell: Neutrophil5.4e-4-0.74--0.287.8e-30.120.9-0.0450.038
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TNFRSF21

BRCA0.650.340.23proteinmRNASCNVmethylationCCRCC0.110.14-0.14proteinmRNASCNVmethylationCOAD0.23proteinmRNASCNVmethylationGBM0.54-0.250.19-0.200.13-0.10proteinmRNASCNVmethylationHNSCC0.53-0.080.19-0.120.13-0.38proteinmRNASCNVmethylationLSCC0.84-0.030.01-0.100.05-0.34proteinmRNASCNVmethylationLUAD0.77-0.010.22-0.140.20-0.11proteinmRNASCNVmethylationOV0.35proteinmRNASCNVmethylationPDAC0.51-0.130.230.030.09-0.02proteinmRNASCNVmethylationUCEC0.310.220.060.10-0.03-0.13proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TNFRSF21 and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.