Basic information
- Full name
- tetratricopeptide repeat domain 22
- Ensembl
- ENSG00000006555.11
- Summary
- This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
Protein product
- ENST00000371276.9 Primary ENSP00000360323.4 (0 phosphosite)
- ENST00000371274.8
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 9.0e-5 | - | -1.7e-6 | - | - | -1.5e-16 | 5.6e-22 | 1.4e-16 | - | 1.2e-4 | - |
protein | -3.1e-6 | - | - | -0.11 | - | -3.1e-20 | 0.46 | 0.6 | - | -0.37 | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of TTC22 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
PROGENy: p53 | 1.7e-9 | -0.44 | - | -0.94 | - | 2.2e-16 | 1.8e-6 | 0.059 | - | 0.46 | - | |
HALLMARK_P53_PATHWAY | 6.8e-6 | -0.94 | - | -0.14 | - | 2.2e-16 | 4.9e-4 | 0.058 | - | -0.32 | - | |
HALLMARK_ESTROGEN_RESPONSE_EARLY | 9.8e-5 | -0.32 | - | 0.91 | - | 6.8e-5 | 9.9e-7 | 0.34 | - | 0.55 | - | |
HALLMARK_HEME_METABOLISM | 3.5e-4 | -0.6 | - | 0.48 | - | 1.1e-4 | 9.1e-3 | 9.9e-3 | - | -0.62 | - | |
KINASE-PSP_P38A/MAPK14 | 9.0e-4 | - | - | - | - | 2.9e-3 | 0.086 | - | - | - | - | |
PROGENy: VEGF | 1.1e-3 | 0.29 | - | 0.99 | - | 1.3e-4 | 5.9e-4 | 0.43 | - | -0.28 | - | |
PATH-NP_TIE2_PATHWAY | 1.3e-3 | - | - | - | - | 2.5e-4 | 0.38 | - | - | - | - | |
HALLMARK_KRAS_SIGNALING_DN | 1.7e-3 | -0.96 | - | 0.62 | - | 1.2e-3 | 0.002 | 0.18 | - | -0.69 | - | |
HALLMARK_ESTROGEN_RESPONSE_LATE | 2.7e-3 | -0.18 | - | 0.6 | - | 5e-7 | 7.7e-6 | -0.65 | - | -0.37 | - | |
Clinical: Sex | 4.1e-3 | - | - | 0.007 | - | 0.036 | 0.6 | 0.01 | - | -0.14 | - |
Cis-association
Associations between omics data of TTC22
Trans-association
Associations of the protein abundance of TTC22 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.