Protein: ENSP00000314608

KLHL11:: kelch like family member 11

Lollipop plot

Phosphosites location and occurrence

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* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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				BRCA		CCRCC		COAD		GBM		HNSCC		LSCC		LUAD		OV		PDAC		UCEC
Site	Sequence	Cohorts	Total	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N
S703	LNMRRVPSSQIEC__	3	49	-	-	-	-	-	-	26	-	-	-	-	-	-	-	7	2	-	-	12	2
S704	NMRRVPSSQIEC___	3	35	-	-	-	-	-	-	-	-	-	-	-	-	-	-	15	2	2	1	6	9

Showing 1 to 2 of 2 rows

Tumor and normal comparison

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Site	Sequence	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
S703	LNMRRVPSSQIEC__	-	-	-	-	-	-	-	-	-	-	-
S704	NMRRVPSSQIEC___	-	-	-	-	-	-	-	-	-	-	-

Showing 1 to 2 of 2 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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			Signed p-values
Phenotype	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
cibersort: NK cell activated	S703	0	-	-	-	-0.31	-	-	-	-	-	0.31
HALLMARK_OXIDATIVE_PHOSPHORYLATION	S703	0.013	-	-	-	0.23	-	-	-	-	-	0.02
cibersort: T cell follicular helper	S703	0.016	-	-	-	0.52	-	-	-	-	-	5.7e-3
PERT-PSP_NOCODAZOLE	S704	0.02	-	-	-	-	-	-	-	0.02	-	-
HALLMARK_DNA_REPAIR	S703	0.026	-	-	-	0.21	-	-	-	-	-	0.059
SBS15 (defective DNA mismatch repair)	S703	0.03	-	-	-	-	-	-	-	-	-	0.03
KINASE-PSP_CDK2	S704	0.035	-	-	-	-	-	-	-	0.035	-	-
HALLMARK_G2M_CHECKPOINT	S703	0.036	-	-	-	0.28	-	-	-	-	-	0.059
HALLMARK_FATTY_ACID_METABOLISM	S703	0.042	-	-	-	0.57	-	-	-	-	-	0.02
HALLMARK_E2F_TARGETS	S703	0.048	-	-	-	0.57	-	-	-	-	-	0.026

Showing 1 to 10 of 516 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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			Signed p-values
Kinase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
FGFR1	S703	8.2e-4	-	-	-	4.8e-3	-	-	-	-	-	0.055
NEK6	S703	2.2e-3	-	-	-	0.048	-	-	-	-	-	0.019
CSNK1D	S703	3.8e-3	-	-	-	0.019	-	-	-	-	-	0.079
EPHA3	S703	0.005	-	-	-	0.005	-	-	-	-	-	-
NME1	S703	0.018	-	-	-	0.031	-	-	-	-	-	0.24
TAF1	S704	0.024	-	-	-	-	-	-	-	0.024	-	-
STK33	S704	0.027	-	-	-	-	-	-	-	0.027	-	-
MELK	S703	0.028	-	-	-	-	-	-	-	-	-	0.028
PRKD2	S703	0.034	-	-	-	0.013	-	-	-	-	-	0.6
CSK	S703	0.035	-	-	-	0.037	-	-	-	-	-	0.37

Showing 1 to 10 of 1076 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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			Signed p-values
Phosphatase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
HDHD3	S703	-3.5e-3	-	-	-	-0.27	-	-	-	-	-	-2.4e-3
BPGM	S704	-0.011	-	-	-	-	-	-	-	-0.011	-	-
PTPRO	S703	-0.019	-	-	-	-0.019	-	-	-	-	-	-
PHLPP2	S703	-0.02	-	-	-	-0.02	-	-	-	-	-	-
PTPN5	S703	-0.024	-	-	-	-0.024	-	-	-	-	-	-
DUSP22	S704	-0.025	-	-	-	-	-	-	-	-0.025	-	-
PTPRT	S703	-0.027	-	-	-	-0.027	-	-	-	-	-	-
PPTC7	S703	-0.031	-	-	-	0.76	-	-	-	-	-	-7.7e-4
PTPN18	S704	-0.035	-	-	-	-	-	-	-	-0.035	-	-
PALD1	S703	-0.036	-	-	-	-0.5	-	-	-	-	-	-0.022

Showing 1 to 10 of 480 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Protein: ENSP00000314608Gene: KLHL11

Lollipop plot

Structure

Phosphosite detection coverage

Tumor and normal comparison

Phenotype and mutation association

Cis-association

Kinase association

Phosphatase association

Protein: ENSP00000314608
Gene: KLHL11