Basic information
- Full name
- ATP binding cassette subfamily B member 11
- Ensembl
- ENSG00000073734.10
- Summary
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
- Annotation
- Druggable target (Tier T4)
Protein product
- ENST00000650372.1 Primary ENSP00000497931.1 (0 phosphosite)
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -7.5e-12 | - | -2.7e-4 | - | - | -1.2e-4 | -0.93 | -2.7e-11 | - | -0.29 | - |
protein | - | - | - | - | - | - | - | - | - | - | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of ABCB11 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
xcell: T cell regulatory (Tregs) | - | - | - | - | - | - | - | - | - | - | - | |
xcell: stroma score | - | - | - | - | - | - | - | - | - | - | - | |
ESTIMATE: StromalScore | - | - | - | - | - | - | - | - | - | - | - | |
ESTIMATE: ImmuneScore | - | - | - | - | - | - | - | - | - | - | - | |
ESTIMATE: ESTIMATEScore | - | - | - | - | - | - | - | - | - | - | - | |
mutation burden | - | - | - | - | - | - | - | - | - | - | - | |
HALLMARK_HYPOXIA | - | - | - | - | - | - | - | - | - | - | - | |
HALLMARK_MITOTIC_SPINDLE | - | - | - | - | - | - | - | - | - | - | - | |
HALLMARK_TGF_BETA_SIGNALING | - | - | - | - | - | - | - | - | - | - | - | |
HALLMARK_DNA_REPAIR | - | - | - | - | - | - | - | - | - | - | - |
Cis-association
Associations between omics data of ABCB11
Trans-association
Associations of the protein abundance of ABCB11 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.