Gene: BCL11A

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
BAF chromatin remodeling complex subunit BCL11A
Ensembl
ENSG00000119866.22
Summary
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Annotation
Cancer driver (Oncogene) Transcription factor

Protein product

  • ENST00000642384.2 Primary ENSP00000496168.1 (38 phosphosites)
  • ENST00000643004.1
  • ENST00000335712.11
  • ENST00000358510.6
  • ENST00000356842.9
  • ENST00000359629.10
  • ENST00000489516.7
  • ENST00000646249.1
  • ENST00000642439.1
  • ENST00000409351.5
  • ENST00000643716.1
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA2.7e-13-5.4e-6---0.252.8e-309.4e-10--3.9e-6-
protein0.11-----6.1e-45.7e-21-0.042---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC12345678910111213log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1415161718192021222324log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012140-2-4-6-8-10-12-14Pan-cancer024681012141618200-2-4-6-8-10-12-14-16-18-20proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of BCL11A with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_SPERMATOGENESIS3.8e-90.007--1.1e-30.146.7e-70.47--0.837.8e-3
KINASE-PSP_GSK3B6.2e-6---0.080.0290.31--0.0253.4e-3
HALLMARK_E2F_TARGETS2.9e-51.6e-3--0.890.0582.7e-40.55--0.790.059
HALLMARK_G2M_CHECKPOINT9.9e-52.6e-4--0.630.113.6e-40.26--0.0220.032
Tumor Purity (WGS)1.7e-4---0.159.8e-36.6e-50.33-0.840.98
cibersort: T cell follicular helper2.4e-46.6e-3--0.426.7e-30.240.11-0.19-0.55
KINASE-PSP_CDK23.7e-49.7e-4--0.690.010.028-0.96--0.330.049
chromosomal instability4.2e-40.061--0.910.133.5e-60.76--0.640.18
HALLMARK_HEDGEHOG_SIGNALING1.4e-30.14--9.4e-30.790.20.39-7.5e-3-0.49
PERT-PSP_NOCODAZOLE2.1e-31.4e-4--0.620.140.017-0.5--0.290.088
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of BCL11A

BRCA0.700.330.27proteinmRNASCNVmethylationCCRCC0.02-0.070.07proteinmRNASCNVmethylationCOAD0.35proteinmRNASCNVmethylationGBM0.450.060.07-0.120.15-0.14proteinmRNASCNVmethylationHNSCC0.42-0.130.07-0.010.38-0.16proteinmRNASCNVmethylationLSCC0.83-0.060.25-0.120.27-0.21proteinmRNASCNVmethylationLUAD0.030.25-0.22-0.170.08-0.03proteinmRNASCNVmethylationOV0.20proteinmRNASCNVmethylationPDAC-0.020.290.08-0.110.150.05proteinmRNASCNVmethylationUCEC0.52-0.130.27-0.220.13-0.22proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of BCL11A and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.