Basic information
- Full name
- CDC28 protein kinase regulatory subunit 2
- Ensembl
- ENSG00000123975.5
- Summary
- CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]
- Annotation
- Essential genes
Protein product
- ENST00000314355.7 Primary ENSP00000364976.3 (0 phosphosite)
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 1.6e-69 | - | 1.2e-4 | - | - | 1.8e-19 | 2.4e-30 | 2.1e-19 | - | 1.3e-9 | - |
protein | 2.1e-4 | - | - | - | - | 0.26 | 3.8e-5 | 0.34 | - | - | 0.22 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of CKS2 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
KINASE-PSP_CDK1 | 5.1e-9 | 0.043 | 0.21 | - | 0.045 | 1.9e-3 | 0.014 | 0.061 | - | 0.39 | 3.3e-3 | |
KINASE-PSP_CDK2 | 8.4e-9 | 0.005 | 0.33 | - | 0.039 | 1.1e-4 | 0.072 | 0.21 | - | 0.39 | 7.5e-3 | |
HALLMARK_G2M_CHECKPOINT | 1.8e-6 | 0.023 | 0.66 | - | 0.04 | 0.019 | 2.8e-3 | 0.49 | - | -0.26 | 1.3e-4 | |
HALLMARK_MYC_TARGETS_V2 | 5.4e-6 | 0.12 | 0.37 | - | 0.44 | 2.1e-4 | 0.023 | 0.32 | - | -0.13 | 3.2e-5 | |
HALLMARK_SPERMATOGENESIS | 1.1e-5 | 0.15 | 0.91 | - | 0.23 | 2.7e-3 | 4.1e-3 | 0.7 | - | -0.81 | 2.5e-4 | |
PERT-PSP_NOCODAZOLE | 1.1e-5 | 2.6e-3 | 0.24 | - | 0.016 | 0.019 | 0.21 | 0.19 | - | 0.92 | 0.41 | |
HALLMARK_MYC_TARGETS_V1 | 2.4e-5 | 0.05 | -0.25 | - | 0.23 | 0.038 | 0.015 | 0.88 | - | 0.61 | 2.1e-6 | |
xcell: T cell CD4+ Th2 | 6.1e-5 | 0.017 | -0.54 | - | 0.061 | 0.047 | 0.14 | 0.74 | - | 0.89 | 1.7e-4 | |
KINASE-PSP_GSK3B | 6.4e-5 | - | - | - | 0.026 | 9.5e-4 | 0.44 | - | - | 0.47 | 0.056 | |
HALLMARK_E2F_TARGETS | 7.0e-5 | 0.034 | -0.29 | - | 0.046 | 0.022 | 2.4e-3 | 0.66 | - | -0.11 | 6.1e-5 |
Cis-association
Associations between omics data of CKS2
Trans-association
Associations of the protein abundance of CKS2 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.