Basic information

Full name
CDC28 protein kinase regulatory subunit 2
Ensembl
ENSG00000123975.5
Summary
CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]
Annotation
Essential genes

Protein product

  • ENST00000314355.7 Primary ENSP00000364976.3 (0 phosphosite)
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.6e-69-1.2e-4--1.8e-192.4e-302.1e-19-1.3e-9-
protein2.1e-4----0.263.8e-50.34--0.22

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC45678910111213log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADPDACUCEC171819202122232425log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820222426280-2-4-6-8-10-12-14-16-18-20-22-24-26-28Pan-cancer0204060801001201401600-20-40-60-80-100-120-140-160proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CKS2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CDK15.1e-90.0430.21-0.0451.9e-30.0140.061-0.393.3e-3
KINASE-PSP_CDK28.4e-90.0050.33-0.0391.1e-40.0720.21-0.397.5e-3
HALLMARK_G2M_CHECKPOINT1.8e-60.0230.66-0.040.0192.8e-30.49--0.261.3e-4
HALLMARK_MYC_TARGETS_V25.4e-60.120.37-0.442.1e-40.0230.32--0.133.2e-5
HALLMARK_SPERMATOGENESIS1.1e-50.150.91-0.232.7e-34.1e-30.7--0.812.5e-4
PERT-PSP_NOCODAZOLE1.1e-52.6e-30.24-0.0160.0190.210.19-0.920.41
HALLMARK_MYC_TARGETS_V12.4e-50.05-0.25-0.230.0380.0150.88-0.612.1e-6
xcell: T cell CD4+ Th26.1e-50.017-0.54-0.0610.0470.140.74-0.891.7e-4
KINASE-PSP_GSK3B6.4e-5---0.0269.5e-40.44--0.470.056
HALLMARK_E2F_TARGETS7.0e-50.034-0.29-0.0460.0222.4e-30.66--0.116.1e-5
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CKS2

BRCA0.250.190.31proteinmRNASCNVmethylationCCRCC0.180.030.100.15-0.080.03proteinmRNASCNVmethylationCOAD0.13proteinmRNASCNVmethylationGBM0.29-0.050.240.060.32-0.21proteinmRNASCNVmethylationHNSCC0.310.050.080.150.45-0.03proteinmRNASCNVmethylationLSCC0.33-0.060.20-0.110.46-0.07proteinmRNASCNVmethylationLUAD0.21-0.18-0.100.070.260.04proteinmRNASCNVmethylationOV0.25proteinmRNASCNVmethylationPDAC0.350.26-0.150.27-0.05proteinmRNASCNVmethylationUCEC0.41-0.02-0.08-0.170.120.14proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CKS2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.