Basic information

Full name
fibroblast growth factor 13
Ensembl
ENSG00000129682.16
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]
Annotation
Ligand

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-2.3e-8--4.8e-11---4.6e-6-0.270.015--8.2e-3-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC123456789101112log2(RSEM+1)tumornormal
Protein expression
BRCALUADUCEC1414.51515.51616.51717.51818.51919.520log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer024681012141618200-2-4-6-8-10-12-14-16-18-20proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of FGF13 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_PROTEIN_SECRETION7.4e-37.4e-3---------
cibersort: Myeloid dendritic cell activated0.0150.015---------
cibersort: B cell plasma0.020.02---------
xcell: T cell CD4+ central memory0.0470.047---------
PROGENy: Androgen0.0790.079---------
Clinical: Age0.0830.083---------
cibersort: T cell CD4+ memory activated0.0980.098---------
KINASE-PSP_mTOR/MTOR0.0990.099---------
PROGENy: MAPK0.10.1---------
HALLMARK_GLYCOLYSIS0.110.11---------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of FGF13

BRCA0.660.180.11proteinmRNASCNVmethylationCCRCC-0.01-0.18-0.01proteinmRNASCNVmethylationCOAD0.24proteinmRNASCNVmethylationGBM-0.02-0.020.02proteinmRNASCNVmethylationHNSCC-0.170.23-0.33proteinmRNASCNVmethylationLSCC-0.16-0.01-0.49proteinmRNASCNVmethylationLUAD-0.110.28-0.23proteinmRNASCNVmethylationOV0.14proteinmRNASCNVmethylationPDAC-0.250.19-0.41proteinmRNASCNVmethylationUCEC-0.220.100.32proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of FGF13 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.