Basic information
- Full name
- sciellin
- Ensembl
- ENSG00000136155.17
- Summary
- The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Protein product
- ENST00000349847.4 Primary ENSP00000302579.5 (48 phosphosites)
- ENST00000377246.7
- ENST00000535157.5
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -2e-44 | - | -8.8e-12 | - | - | -7.4e-19 | -7.4e-31 | -2.7e-20 | - | 1.9e-7 | - |
protein | -7.5e-35 | - | - | - | - | -6.2e-21 | -4.4e-35 | -2.5e-28 | -0.036 | 2.1e-13 | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of SCEL with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_P53_PATHWAY | 3.4e-21 | 0.32 | - | - | - | 2.2e-16 | 2.6e-4 | 0.36 | 6.7e-5 | 0.011 | 2.6e-6 | |
PROGENy: p53 | 1.4e-14 | 0.38 | - | - | - | 2.2e-16 | 0.039 | 9.6e-3 | 0.39 | 0.49 | 3.9e-7 | |
HALLMARK_ESTROGEN_RESPONSE_LATE | 6.3e-12 | -0.21 | - | - | - | 6.4e-5 | 2.2e-8 | 0.97 | 0.067 | -0.81 | 2.2e-16 | |
HALLMARK_APICAL_SURFACE | 4.3e-11 | 0.29 | - | - | - | 5.3e-4 | 2.3e-4 | -0.69 | 0.11 | 9.1e-4 | 2.3e-6 | |
PROGENy: MAPK | 7e-11 | 0.076 | - | - | - | 0.032 | 1e-7 | 0.43 | 0.52 | 0.008 | 8.5e-5 | |
HALLMARK_ESTROGEN_RESPONSE_EARLY | 1.1e-10 | -0.1 | - | - | - | 1.3e-3 | 1.5e-9 | 0.11 | 0.15 | -0.91 | 5.9e-11 | |
PROGENy: EGFR | 9.2e-10 | 0.092 | - | - | - | 0.001 | 1.8e-6 | -0.93 | 0.37 | 0.066 | 1.4e-4 | |
PROGENy: VEGF | 1.4e-7 | 0.76 | - | - | - | 5.7e-6 | 0.021 | 0.045 | 0.023 | 0.42 | 0.089 | |
PROGENy: WNT | 3.2e-7 | 0.14 | - | - | - | -0.43 | 0.001 | 0.57 | 0.35 | 2.6e-8 | 0.013 | |
HALLMARK_COAGULATION | 4.2e-6 | 0.2 | - | - | - | 0.92 | 3.9e-6 | 0.78 | 0.078 | 0.59 | 3.3e-4 |
Cis-association
Associations between omics data of SCEL
Trans-association
Associations of the protein abundance of SCEL and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.