Gene: TRAF1

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
TNF receptor associated factor 1
Ensembl
ENSG00000056558.11
Summary
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.6e-6-3.2e-4--2.9e-8-0.726.9e-4--0.14-
protein3e-20-1.4e-43.8e-6-6.2e-98.1e-42.2e-9-0.013.7e-8-0.66

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC5.566.577.588.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC171819202122232425log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416182022240-2-4-6-8-10-12-14-16-18-20-22-24Pan-cancer01020304050607080901001100-10-20-30-40-50-60-70-80-90-100-110proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TRAF1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: ImmuneScore2.2e-922.2e-168.5e-53.9e-42.2e-162.2e-162.2e-162.2e-165.1e-42.0e-52.2e-16
HALLMARK_ALLOGRAFT_REJECTION8.2e-892.2e-163.3e-52.7e-42.2e-162.2e-162.2e-162.2e-161.0e-42.5e-68.8e-9
xcell: immune score2.4e-752.2e-166.1e-33.9e-32.2e-162.2e-162.2e-162.2e-160.0178.1e-53.7e-7
xcell: Myeloid dendritic cell activated3.6e-691.2e-121.5e-50.022-0.451.8e-177.5e-219.8e-248.2e-51.2e-84.2e-7
HALLMARK_IL6_JAK_STAT3_SIGNALING8.9e-692.2e-162.4e-36.0e-42.2e-162.2e-162.2e-161.8e-61.9e-41.1e-31.2e-5
HALLMARK_IL2_STAT5_SIGNALING4.1e-682e-91.2e-42.7e-42.2e-162.2e-162.2e-165.7e-81.2e-41.4e-35.0e-6
ESTIMATE: ESTIMATEScore7.8e-683.8e-40.012.7e-42.2e-162.2e-162.2e-165.4e-106.8e-44.7e-32.2e-16
xcell: microenvironment score6.4e-662.5e-50.0030.0352.2e-162.2e-162.2e-162.2e-162.9e-32.3e-31.3e-9
HALLMARK_INTERFERON_GAMMA_RESPONSE3.5e-602.2e-161.5e-50.0041.3e-62.2e-162.2e-167.9e-76.8e-31.6e-31.9e-5
xcell: Myeloid dendritic cell1.9e-584.1e-113.2e-30.0140.228.8e-133.4e-175.5e-165.6e-42.2e-75.7e-8
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TRAF1

BRCA0.610.100.17proteinmRNASCNVmethylationCCRCC0.640.060.080.000.210.05proteinmRNASCNVmethylationCOAD0.48-0.400.11proteinmRNASCNVmethylationGBM0.71-0.230.25-0.320.24-0.02proteinmRNASCNVmethylationHNSCC0.830.030.000.04-0.060.17proteinmRNASCNVmethylationLSCC0.810.220.140.070.29-0.08proteinmRNASCNVmethylationLUAD0.780.050.280.090.270.02proteinmRNASCNVmethylationOV0.500.270.32proteinmRNASCNVmethylationPDAC0.57-0.090.10-0.190.19-0.14proteinmRNASCNVmethylationUCEC0.75-0.02-0.20-0.140.02-0.07proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TRAF1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.