Gene: CD209

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
CD209 molecule
Ensembl
ENSG00000090659.18
Summary
This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020]
Annotation
Receptor

Protein product

  • ENST00000315599.12 Primary ENSP00000315477.6 (0 phosphosite)
  • ENST00000394173.8
  • ENST00000394161.9
  • ENST00000354397.10
  • ENST00000601951.5
  • ENST00000315591.12
  • ENST00000204801.12
  • ENST00000593660.5
  • ENST00000602261.5
  • ENST00000601256.1
  • ENST00000593821.5
Phosphosites on the primary protein product

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA7.2e-4-5e-9--0.210.620.16--0.16-
protein-9.3e-15-0.62-7.1e-12--0.056-8.1e-6-1.1e-10-0.61-0.067

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC3456789101112log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADHNSCCLSCCLUADOVPDACUCEC171819202122232425log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416180-2-4-6-8-10-12-14-16-18Pan-cancer01020304050607080900-10-20-30-40-50-60-70-80-90proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CD209 with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Myeloid dendritic cell6.5e-251.1e-30.11.1e-4-2.4e-111.1e-102.3e-30.843.7e-50.096
ESTIMATE: StromalScore1.3e-213.4e-47.3e-40.024-9.2e-89.4e-77.4e-40.933.4e-40.032
HALLMARK_KRAS_SIGNALING_UP2.2e-212.3e-50.0890.024-6.3e-72.2e-78.3e-40.660.011.6e-4
ESTIMATE: ESTIMATEScore2.7e-211.3e-30.214.8e-3-1.5e-84.9e-73.0e-5-0.742.0e-50.019
xcell: microenvironment score3.1e-214.8e-50.160.008-1.2e-78.3e-61.8e-5-0.881.5e-50.042
HALLMARK_IL2_STAT5_SIGNALING6.8e-173.3e-3-0.560.014-7.3e-72.6e-71.5e-5-0.724.3e-39.0e-4
HALLMARK_IL6_JAK_STAT3_SIGNALING1.9e-168.9e-3-0.784.7e-3-9.5e-74.7e-69.4e-6-0.898.2e-40.017
ESTIMATE: ImmuneScore1.4e-150.029-0.416.3e-3-9.3e-86.4e-66.9e-6-0.471.9e-50.05
HALLMARK_ALLOGRAFT_REJECTION1e-140.024-0.450.039-1.1e-64.7e-63.8e-6-0.711.4e-50.11
xcell: Endothelial cell2.3e-144.7e-30.0330.096-5.3e-42.4e-52.7e-5-0.30.0311.1e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CD209

BRCA0.660.200.14proteinmRNASCNVmethylationCCRCC0.700.03-0.02proteinmRNASCNVmethylationCOAD0.28-0.110.14proteinmRNASCNVmethylationGBM-0.08proteinmRNASCNVmethylationHNSCC0.790.170.08proteinmRNASCNVmethylationLSCC0.810.090.04proteinmRNASCNVmethylationLUAD0.650.160.23proteinmRNASCNVmethylationOV0.590.10-0.07proteinmRNASCNVmethylationPDAC0.600.010.09proteinmRNASCNVmethylationUCEC0.570.030.06proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CD209 and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.