Basic information

Full name
LIM domain kinase 1
Ensembl
ENSG00000106683.15
Summary
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
Annotation
Druggable target (Tier T3) Protein Kinase

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA9.1e-63-2e-14--1.4e-203.6e-163.7e-25-0.053-
protein2.3e-22-9.1e-14-3.3e-3-7.2e-177.9e-43.5e-120.652.2e-6-0.4

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416182022240-2-4-6-8-10-12-14-16-18-20-22-24Pan-cancer0510152025303540450-5-10-15-20-25-30-35-40-45proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of LIMK1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Macrophage8.7e-462.6e-53.3e-80.427.9e-32.9e-164.9e-111.2e-78.9e-47.1e-51.2e-5
xcell: Macrophage M15.2e-411.4e-63.8e-90.226.6e-31.4e-112.2e-165.7e-61.6e-30.353.6e-5
ESTIMATE: ImmuneScore2.6e-363.5e-71.1e-70.270.0333.8e-85.1e-93.8e-42.4e-50.0212.2e-6
HALLMARK_ALLOGRAFT_REJECTION2.8e-361.3e-77e-80.0650.0732.2e-72.3e-92.2e-42.1e-40.0166.6e-6
HALLMARK_INFLAMMATORY_RESPONSE2e-342.2e-162.7e-50.0910.0261.5e-54e-71.3e-42.7e-40.0328.0e-4
ESTIMATE: ESTIMATEScore1.7e-331.6e-72.2e-40.790.0649.1e-109e-91.1e-41.2e-67.4e-31.3e-4
xcell: immune score2.2e-332.7e-58.7e-100.420.0295.7e-85.5e-82.4e-42.3e-44.3e-32.4e-4
HALLMARK_COMPLEMENT7.1e-331.3e-91.2e-50.170.022.5e-84.5e-81.7e-36.3e-50.0358.9e-4
HALLMARK_IL6_JAK_STAT3_SIGNALING7.1e-321.4e-81.8e-60.0170.0842.1e-51e-73.0e-48.7e-50.0543.8e-4
HALLMARK_INTERFERON_GAMMA_RESPONSE5.5e-301.3e-67.7e-70.0430.185.3e-43.6e-83.0e-65.4e-36.8e-32.2e-4
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of LIMK1

BRCA0.540.210.15proteinmRNASCNVmethylationCCRCC0.710.050.14-0.070.18-0.17proteinmRNASCNVmethylationCOAD0.130.030.26proteinmRNASCNVmethylationGBM0.660.030.030.020.05-0.15proteinmRNASCNVmethylationHNSCC0.430.01-0.06-0.030.280.01proteinmRNASCNVmethylationLSCC0.66-0.030.29-0.110.46-0.10proteinmRNASCNVmethylationLUAD0.770.050.620.040.680.21proteinmRNASCNVmethylationOV0.500.070.43proteinmRNASCNVmethylationPDAC0.26-0.02-0.11-0.210.23-0.05proteinmRNASCNVmethylationUCEC0.45-0.090.09-0.080.26-0.06proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of LIMK1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.