Basic information
- Full name
- minichromosome maintenance complex component 3
- Ensembl
- ENSG00000112118.20
- Summary
- The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]
- Annotation
- Essential genes
Protein product
- ENST00000596288.7 Primary ENSP00000472940.2 (22 phosphosites)
- ENST00000616552.4
- ENST00000229854.12
- ENST00000419835.8
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 1.6e-73 | - | 1.6e-8 | - | - | 2.8e-15 | 1.6e-33 | 1.1e-22 | - | 2.7e-7 | - |
protein | 9.5e-123 | - | 1.7e-28 | 7.8e-25 | - | 1.1e-13 | 5.8e-35 | 4.3e-26 | 1.6e-8 | 1.8e-11 | 0.01 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of MCM3 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_G2M_CHECKPOINT | 3.1e-163 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.4e-34 | |
HALLMARK_E2F_TARGETS | 7.8e-146 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 1e-13 | 2.2e-16 | |
KINASE-PSP_CDK2 | 4.1e-104 | 2.2e-16 | 1.0e-6 | 1e-8 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 1.7e-4 | 1.0e-6 | 2.2e-16 | |
HALLMARK_MYC_TARGETS_V2 | 2.2e-86 | 4.6e-16 | 4.4e-4 | 1.0e-5 | 2.2e-16 | 1.7e-10 | 2.2e-16 | 2.2e-16 | 1.6e-3 | 1.2e-4 | 2.2e-16 | |
HALLMARK_MYC_TARGETS_V1 | 6.8e-80 | 2.2e-16 | 2.0e-5 | 2.0e-4 | 2.2e-16 | 7.4e-4 | 2.2e-16 | 2.2e-16 | 1.1e-3 | 2.7e-5 | 2.2e-16 | |
HALLMARK_SPERMATOGENESIS | 1.1e-74 | 2.2e-16 | 0.037 | 2.2e-16 | 5.8e-4 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 3.9e-5 | 0.02 | 1.5e-6 | |
KINASE-PSP_CDK1 | 2.1e-65 | 2.2e-16 | 0.17 | 5.9e-4 | 2.2e-16 | 5.5e-7 | 1.4e-8 | 2.2e-16 | 2.2e-4 | 1.1e-5 | 6.4e-9 | |
HALLMARK_DNA_REPAIR | 1.6e-64 | 1.6e-6 | 1.1e-3 | 5.7e-5 | 2.2e-16 | 9e-7 | 2.2e-16 | 1.6e-8 | 0.055 | 8.4e-6 | 2.2e-16 | |
HALLMARK_MITOTIC_SPINDLE | 3.1e-58 | 3.5e-10 | 3.8e-4 | 0.37 | 2.2e-16 | 5.8e-4 | 8.1e-4 | 2.2e-16 | 3.2e-4 | 2.9e-7 | 2.2e-16 | |
PERT-PSP_NOCODAZOLE | 1.3e-56 | 3.2e-15 | 0.015 | 0.41 | 1.0e-5 | 1e-8 | 2.2e-16 | 2.2e-16 | 1.7e-4 | 4.6e-4 | 2.4e-7 |
Cis-association
Associations between omics data of MCM3
Trans-association
Associations of the protein abundance of MCM3 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
MCM2 | 1.5e-148 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | |
MCM7 | 1.5e-148 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | |
FEN1 | 1.5e-148 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | |
MCM4 | 1.5e-148 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | |
MCM6 | 1.5e-148 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | |
MCM5 | 1.5e-148 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | |
SMC2 | 3.7e-139 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 3.2e-8 | 2.2e-16 | |
SMC4 | 2.1e-137 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 5.1e-7 | 2.2e-16 | |
POLD1 | 8.9e-133 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 6.6e-9 | 1.3e-9 | 2.2e-16 | |
HAT1 | 3.5e-131 | 2.2e-16 | 1.5e-7 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 8e-10 | 2.2e-16 |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.