Basic information

Full name
NGFI-A binding protein 2
Ensembl
ENSG00000166886.13
Summary
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Annotation
Cancer driver (TSG)

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.9e-4--0.5--0.0821.7e-40.049-0.12-
protein2.8e-5-2.9e-4--0.022.3e-8-0.80.472.5e-4-4.9e-6

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.51212.513log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC16171819202122232425262728log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12Pan-cancer02468101214160-2-4-6-8-10-12-14-16proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of NAB2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Common lymphoid progenitor2.5e-114.3e-50.170.60.0830.384.2e-37.4e-41.7e-4-0.471.2e-3
HALLMARK_E2F_TARGETS1e-70.0380.990.131.2e-50.0211.2e-3-0.870.0340.066-0.61
HALLMARK_G2M_CHECKPOINT4.1e-70.0370.790.146.6e-62.9e-32.5e-3-0.660.340.17-0.86
HALLMARK_MYC_TARGETS_V21.8e-60.680.460.524.1e-80.447.4e-50.287.6e-3-0.92-0.56
chromosomal instability3.7e-60.0120.15-0.160.0112.1e-54.4e-8-0.0760.015-0.51-0.85
PROGENy: MAPK2.7e-50.260.150.569.2e-7-0.520.620.017-0.740.180.054
HALLMARK_SPERMATOGENESIS7.5e-50.0910.390.052-0.448.9e-34.0e-5-0.572.2e-30.18-0.087
HALLMARK_DNA_REPAIR1.5e-40.350.470.585.8e-70.920.0410.440.0370.45-0.33
HALLMARK_MITOTIC_SPINDLE1.7e-40.0430.66-0.851.5e-30.358.1e-3-0.480.50.0210.57
HALLMARK_WNT_BETA_CATENIN_SIGNALING3.7e-40.240.019-0.0110.114.2e-41.1e-40.61-0.720.390.8
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of NAB2

BRCA0.560.120.27proteinmRNASCNVmethylationCCRCC0.42-0.080.27-0.010.08-0.17proteinmRNASCNVmethylationCOAD0.390.130.11proteinmRNASCNVmethylationGBM0.55-0.030.300.040.36-0.09proteinmRNASCNVmethylationHNSCC0.72-0.100.29-0.060.370.03proteinmRNASCNVmethylationLSCC0.84-0.090.43-0.150.30-0.12proteinmRNASCNVmethylationLUAD0.60-0.100.23-0.210.25-0.11proteinmRNASCNVmethylationOV0.720.280.36proteinmRNASCNVmethylationPDAC0.23-0.100.16-0.170.31-0.16proteinmRNASCNVmethylationUCEC0.61-0.080.09-0.010.16-0.18proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of NAB2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
BRD4 1.1e-210.176.7e-67.3e-33.0e-51.4e-65.5e-7-0.921.4e-30.0310.014
GPATCH8 1.5e-205.3e-55.1e-50.0582.8e-60.0113.1e-40.470.0082.2e-40.14
SAP130 9.6e-202.7e-30.0260.067.8e-64.3e-41.1e-30.113.0e-50.0180.023
C12orf10 2.1e-190.290.0850.684.0e-51.0e-42.2e-160.179.3e-9-0.539.7e-3
CCNT1 7.9e-193.4e-30.0274.6e-32e-86.5e-41.3e-50.147.4e-30.0470.61
SFSWAP 1.1e-180.0181.0e-40.221.6e-84.9e-33.5e-63.7e-32.4e-30.840.24
UBXN7 1.5e-180.0290.02810.129e-75.6e-110.341.2e-42.4e-30.25
SP1 1.7e-180.171.4e-59.5e-30.0011.4e-83.5e-40.323.4e-40.250.23
TPR 1.9e-180.191.3e-50.746.4e-66.1e-62.6e-50.242.4e-40.0580.085
NAB1 4.5e-182.1e-50.043-1.4e-40.0690.150.0129.6e-50.0955.2e-6
Showing 1 to 10 of 19700 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.