Gene: PIK3R5

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
phosphoinositide-3-kinase regulatory subunit 5
Ensembl
ENSG00000141506.13
Summary
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-9e-7-3.3e-28--1.4e-6-2.4e-25-2e-25--1.4e-3-
protein-1.2e-11------1.1e-4-9.6e-9---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC456789101112log2(RSEM+1)tumornormal
Protein expression
BRCAGBMHNSCCLSCCLUADPDAC1112131415161718192021log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530350-5-10-15-20-25-30-35Pan-cancer0204060801001201401601802002202400-20-40-60-80-100-120-140-160-180-200-220-240proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PIK3R5 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Macrophage M17.2e-100.12--8.2e-40.281.9e-62.6e-3---
xcell: immune score8.1e-100.15--0.0030.179.7e-72.4e-3---
xcell: Monocyte2.4e-9-0.78--6.5e-30.121.4e-99.9e-4---
xcell: Macrophage2.6e-90.079--4.2e-30.375.4e-61.2e-3---
ESTIMATE: ImmuneScore5.5e-90.56--3.7e-30.262.6e-70.001---
HALLMARK_ALLOGRAFT_REJECTION8.4e-90.78--4.3e-30.0967.2e-71.8e-3---
HALLMARK_COMPLEMENT9.1e-90.52--9.1e-30.181.5e-72.7e-3---
HALLMARK_INFLAMMATORY_RESPONSE9.3e-90.56--6.5e-30.611.8e-86.8e-4---
ESTIMATE: ESTIMATEScore1.2e-80.51--2.6e-30.0962.3e-67.2e-3---
HALLMARK_IL6_JAK_STAT3_SIGNALING1.7e-80.88--4.4e-30.454.4e-87.2e-4---
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PIK3R5

BRCA0.25-0.14-0.21proteinmRNASCNVmethylationCCRCC-0.060.31-0.10proteinmRNASCNVmethylationCOAD0.28proteinmRNASCNVmethylationGBM0.65-0.06-0.12-0.280.24-0.05proteinmRNASCNVmethylationHNSCC0.240.360.240.01-0.030.21proteinmRNASCNVmethylationLSCC0.570.180.010.070.270.06proteinmRNASCNVmethylationLUAD0.450.030.18-0.060.230.08proteinmRNASCNVmethylationOV0.22proteinmRNASCNVmethylationPDAC-0.300.27-0.16proteinmRNASCNVmethylationUCEC-0.04-0.160.03proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PIK3R5 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.