Basic information
- Full name
- sphingosine-1-phosphate phosphatase 1
- Ensembl
- ENSG00000126821.8
- Summary
- Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]
- Annotation
- Phosphatase
Protein product
- ENST00000247225.7 Primary ENSP00000247225.6 (3 phosphosites)
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -1.3e-4 | - | -1.8e-28 | - | - | 3.3e-14 | -1.4e-13 | 7.5e-4 | - | -0.29 | - |
protein | -1.9e-5 | - | -1.1e-17 | -0.91 | - | 2.1e-16 | -3.1e-6 | 1.3e-5 | -0.15 | -7.1e-6 | -7.9e-8 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of SGPP1 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
xcell: Macrophage | 1.2e-13 | 0.026 | 0.052 | 0.43 | 0.15 | 0.059 | 7.6e-7 | 0.21 | 0.016 | 1.8e-4 | 4.9e-3 | |
xcell: Macrophage M1 | 4.3e-13 | 0.045 | 0.061 | 0.92 | 0.16 | 0.068 | 2.9e-7 | 0.19 | 0.016 | 3.7e-4 | 0.001 | |
HALLMARK_INFLAMMATORY_RESPONSE | 1.9e-12 | 0.16 | 0.19 | 0.14 | 0.6 | 2.2e-3 | 7.0e-5 | 0.21 | 6.0e-4 | 9.7e-4 | 0.012 | |
HALLMARK_INTERFERON_GAMMA_RESPONSE | 2.6e-12 | 0.16 | 1.8e-4 | 0.26 | 0.16 | 0.16 | 4.4e-7 | 0.51 | 4.2e-3 | 0.015 | 0.044 | |
HALLMARK_COMPLEMENT | 7.8e-12 | 0.041 | 0.092 | 0.42 | 0.62 | 0.029 | 3.9e-6 | 0.45 | 1.1e-3 | 6.3e-3 | 2.3e-3 | |
HALLMARK_IL6_JAK_STAT3_SIGNALING | 1.4e-11 | 0.56 | 0.033 | 0.066 | 0.67 | 0.012 | 4.4e-5 | 0.45 | 3.9e-4 | 3.1e-3 | 0.012 | |
ESTIMATE: ImmuneScore | 1.8e-11 | 0.14 | 1.9e-3 | 0.3 | 0.25 | 0.042 | 4.4e-5 | -0.54 | 4.2e-4 | 0.018 | 0.002 | |
xcell: Plasmacytoid dendritic cell | 3.6e-11 | 0.18 | 0.14 | 0.21 | 0.57 | 0.027 | 3.8e-4 | 8.6e-3 | 7.4e-3 | 0.023 | 0.003 | |
HALLMARK_ALLOGRAFT_REJECTION | 4.5e-11 | 0.29 | 1.5e-3 | 0.33 | 0.38 | 0.021 | 5.6e-6 | -0.91 | 7.3e-4 | 0.082 | 3.9e-3 | |
HALLMARK_INTERFERON_ALPHA_RESPONSE | 5.2e-11 | 0.12 | 3.7e-6 | 0.4 | 0.057 | 0.28 | 8.0e-6 | 0.72 | 0.05 | 0.015 | 0.12 |
Cis-association
Associations between omics data of SGPP1
Trans-association
Associations of the protein abundance of SGPP1 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.