Protein: ENSP00000381066
Gene: MAP2K7

LinkedOmicsKB © 2022-2023 Zhang Lab

MAP2K7:
mitogen-activated protein kinase kinase 7

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S35IDLNLDISPQRPRPT630671-2919--45-4525292698------
S53PLANDGGSRSPSSES18------------------53
S55ANDGGSRSPSSESSP326----549-------71----
S60SRSPSSESSPQHPTP19------9-------------
S61RSPSSESSPQHPTPP833133---464389-41231010--7242192
T66ESSPQHPTPPARPRH461----171017-------62---9
S86STLFTPRSMESIEID485--44----53--54----519
S89FTPRSMESIEIDQKL226------18-----44------
S271ISGRLVDSKAKTRSA19--------------72----
T295RIDPPDPTKPDYDIR245----2115--------81----
Showing 1 to 10 of 15 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S35IDLNLDISPQRPRPT4.4e-7-4.5e-4--0.141.6e-4----
S53PLANDGGSRSPSSES-----------
S55ANDGGSRSPSSESSP-----------
S60SRSPSSESSPQHPTP-----------
S61RSPSSESSPQHPTPP-0.46---0.73--0.48-----
T66ESSPQHPTPPARPRH-----------
S86STLFTPRSMESIEID-----------
S89FTPRSMESIEIDQKL-----------
S271ISGRLVDSKAKTRSA-----------
T295RIDPPDPTKPDYDIR4.5e-5--4.5e-5-------
Showing 1 to 10 of 15 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_SPERMATOGENESISS357.7e-84.9e-30.74-0.0264.4e-41.7e-3----
HALLMARK_E2F_TARGETSS351.1e-71.1e-30.2-0.131.5e-38.9e-3----
KINASE-PSP_CDK2S357.8e-63.7e-30.07-0.383.9e-40.38----
HALLMARK_G2M_CHECKPOINTS359.0e-69.1e-40.3-0.140.050.033----
HALLMARK_DNA_REPAIRS619.5e-6-0.71-0.580.910.452.2e-16---0.11
PERT-PSP_NOCODAZOLES352.5e-50.0161.7e-3-0.530.130.082----
HALLMARK_MYC_TARGETS_V2S353.2e-50.10.16-0.421.2e-30.026----
KINASE-PSP_CDK1S351.4e-49.3e-31.3e-3--0.980.0160.76----
KINASE-PSP_CDK2S612.0e-40.018-0.510.0160.071-0.89---0.047
HALLMARK_MYC_TARGETS_V1S352.1e-40.0160.26-0.60.0170.067----
Showing 1 to 10 of 3870 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS35S53S55S60S61T66S86S89S271T295Y299S378T401S403S411proteinRNASCNVmethylationCCRCCS35S53S55S60S61T66S86S89S271T295Y299S378T401S403S411proteinRNASCNVmethylationCOADS35S53S55S60S61T66S86S89S271T295Y299S378T401S403S411proteinRNASCNVmethylationGBMS35S53S55S60S61T66S86S89S271T295Y299S378T401S403S411proteinRNASCNVmethylationHNSCCS35S53S55S60S61T66S86S89S271T295Y299S378T401S403S411proteinRNASCNVmethylationLSCCS35S53S55S60S61T66S86S89S271T295Y299S378T401S403S411proteinRNASCNVmethylationLUADS35S53S55S60S61T66S86S89S271T295Y299S378T401S403S411proteinRNASCNVmethylationOVS35S53S55S60S61T66S86S89S271T295Y299S378T401S403S411proteinRNASCNVmethylationPDACS35S53S55S60S61T66S86S89S271T295Y299S378T401S403S411proteinRNASCNVmethylationUCECS35S53S55S60S61T66S86S89S271T295Y299S378T401S403S411proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
TNS2S35-1.1e-6-1.2e-3-4.6e-3--0.11-0.31-0.03----
TNS3S35-2.7e-40.69-8.1e-6--0.012-0.66-0.26----
PGAM2S35-2.9e-4-4.2e-30.77--0.27-0.043-0.016----
SACM1LS403-7.7e-4-7.7e-4---------
SGPP1S403-8.0e-4-8.0e-4---------
PPP1CCS403-0.001-0.001---------
SSH1S35-1.3e-3-0.36-0.28--0.19-0.52-1.3e-3----
FIG4S35-1.6e-3-0.22-0.99--0.076-0.2-5.6e-3----
PPM1FS35-2.2e-30.64-0.005--0.52-0.64-6.5e-4----
PPP3CAS35-2.9e-3-0.34-0.016-0.11-0.061-2.7e-3----
Showing 1 to 10 of 3600 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.